Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.58 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629162 | 0.85 | EGFR (0.79) | EGFRERBB2ERBB4MAP3K8MAPT | |
| SCHEMBL7763005 | 0.84 | EGFR (0.61) | EGFRERBB2ERBB4MAPT | |
| SCHEMBL8110759 | 0.82 | EGFR (0.74) | EGFRERBB2ERBB4 | |
| SCHEMBL2994255 | 0.80 | EGFR (0.83) | EGFRERBB2 | |
| SCHEMBL4007243 | 0.79 | CYP1A2 (0.67) | EGFRALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8104967 | 0.78 | EGFR (0.57) | EGFRERBB2ERBB4 | |
| SCHEMBL11304 | 0.78 | EGFR (0.86) | EGFRERBB2ERBB4MAPT | |
| SCHEMBL30416288 | 0.78 | EGFR (0.86) | EGFRERBB2ERBB4MAPT | |
| SCHEMBL13192086 | 0.77 | CYP1A2 (0.72) | EGFRALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13755815 | 0.77 | EGFR (0.62) | EGFRERBB2ERBB4KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6015814-A | Quinazoline derivative | ZENECA LIMITED (GB) | 2000-01-18 | — | — | US | disclosed |