Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.54 |
| ▸ | MMP2 | P08253 | 10/20 | 0.46 |
| ▸ | MMP3 | P08254 | 7/20 | 0.46 |
| ▸ | MMP1 | P03956 | 5/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | PTAFR | P25105 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | MMP14 | P50281 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7763158 | 1.00 | MMP12 (0.54) | MMP12MMP2MMP3MMP1MMP7 | |
| SCHEMBL7762276 | 0.91 | MMP12 (0.50) | MMP12MMP2MMP3PTAFRMMP9 | |
| SCHEMBL7762278 | 0.91 | MMP12 (0.50) | MMP12MMP2MMP3PTAFRMMP9 | |
| SCHEMBL7762255 | 0.81 | MMP2 (0.49) | MMP12MMP2MMP3MMP9MMP14 | |
| SCHEMBL7762366 | 0.79 | MMP2 (0.56) | MMP2MMP3MMP1MMP7MMP9 | |
| SCHEMBL7762107 | 0.79 | MMP2 (0.51) | MMP2MMP3MMP1MMP7MMP9 | |
| SCHEMBL7762108 | 0.79 | MMP2 (0.51) | MMP2MMP3MMP1MMP7MMP9 | |
| SCHEMBL6270502 | 0.79 | MMP12 (0.64) | MMP12MMP2MMP3MMP1MMP7 | |
| SCHEMBL6270497 | 0.79 | MMP12 (0.64) | MMP12MMP2MMP3MMP1MMP7 | |
| SCHEMBL8047955 | 0.71 | MMP12 (0.56) | MMP12PTAFRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | claimed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | claimed |
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |