Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.35 |
| ▸ | FDPS | P14324 | 3/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11118537 | 1.00 | LMNA (0.39) | LMNADNM1TSHRTHRBOPRM1 | |
| SCHEMBL5144286 | 0.91 | LMNA (0.39) | LMNADNM1TSHRTHRBOPRM1 | |
| SCHEMBL29048591 | 0.91 | LMNA (0.39) | LMNADNM1TSHRTHRBOPRM1 | |
| SCHEMBL4600945 | 0.90 | — | — | |
| SCHEMBL8596670 | 0.88 | OPRM1 (0.39) | LMNADNM1TSHRTHRBOPRM1 | |
| SCHEMBL23951461 | 0.87 | TSHR (0.50) | LMNADNM1TSHRTHRBOPRM1 | |
| SCHEMBL2892345 | 0.87 | TSHR (0.50) | LMNADNM1TSHRTHRBOPRM1 | |
| SCHEMBL31596116 | 0.87 | TSHR (0.50) | LMNADNM1TSHRTHRBOPRM1 | |
| SCHEMBL18722590 | 0.87 | TSHR (0.50) | LMNADNM1TSHRTHRBOPRM1 | |
| SCHEMBL28474884 | 0.87 | TSHR (0.50) | LMNADNM1TSHRTHRBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |
| US-5145869-A | Treatment of irritable bowel syndrome, dyskinesia, pancreatist; hormone inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1992-09-08 | — | — | US | disclosed |