SCHEMBL7763192

SCHEMBL7763192

COC(=O)Cc1ccc(Nc2ccc(C)c(C)c2)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.66
NPC1 O15118 4/20 0.66
RAB9A P51151 4/20 0.66
CYP4F2 P78329 1/20 0.50
CYP4A11 Q02928 1/20 0.50
POLB P06746 1/20 0.47
KMT2A Q03164 2/20 0.47
MEN1 O00255 1/20 0.47
HTT P42858 1/20 0.47
ALDH1A1 P00352 4/20 0.46
MAPT P10636 3/20 0.46
TP53 P04637 2/20 0.46
LMNA P02545 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
GAA P10253 1/20 0.45
GFER P55789 1/20 0.45
EPHX2 P34913 1/20 0.45
HSP90AB1 P08238 1/20 0.45
KDM4E B2RXH2 1/20 0.45
CHEK1 O14757 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6289443 0.85 SMN1; SMN2 (0.49) SMN1; SMN2NPC1RAB9ACYP4F2CYP4A11
SCHEMBL8653200 0.84 MAPT (0.49) SMN1; SMN2NPC1RAB9APOLBKMT2A
SCHEMBL31324186 0.83 CYP4F2 (0.56) SMN1; SMN2NPC1RAB9ACYP4F2CYP4A11
SCHEMBL1786183 0.83 NPC1 (0.63) SMN1; SMN2NPC1RAB9ACYP4F2CYP4A11
SCHEMBL7761596 0.82 EPHX2 (0.49) SMN1; SMN2NPC1RAB9APOLBKMT2A
SCHEMBL31324197 0.80 HPGD (0.58) SMN1; SMN2NPC1RAB9ACYP4F2CYP4A11
SCHEMBL31324172 0.79 SMN1; SMN2 (0.56) SMN1; SMN2NPC1RAB9ACYP4F2CYP4A11
SCHEMBL31324194 0.79 ALDH1A1 (0.63) SMN1; SMN2NPC1RAB9ACYP4F2CYP4A11
SCHEMBL31324190 0.79 MAPT (0.63) CYP4F2CYP4A11POLBKMT2AMEN1
SCHEMBL31324158 0.79 MEN1 (0.63) SMN1; SMN2NPC1RAB9ACYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0755916-B1 Process for the preparation of amine compound FUJI XEROX CO LTD (JP) 2001-04-25 EP disclosed
EP-0686879-B1 Charge-transporting polymer and organic electronic device using the same FUJI XEROX CO LTD (JP) 2000-05-24 EP disclosed
US-5604064-A USEFUL IN ELECTROPHOTOGRAPHIC PHOTORECEPTORS FUJI XEROX CO., LTD. (JP) 1997-02-18 US disclosed
EP-0755916-A2 Process for the preparation of amine compound FUJI XEROX CO., LTD. (JP) 1997-01-29 EP disclosed
EP-0686879-A1 Charge-transporting polymer and organic electronic device using the same FUJI XEROX CO., LTD. (JP) 1995-12-13 EP disclosed