Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.71 |
| ▸ | HTR7 | P34969 | 3/20 | 0.71 |
| ▸ | DRD2 | P14416 | 2/20 | 0.71 |
| ▸ | HTR1D | P28221 | 2/20 | 0.71 |
| ▸ | DRD3 | P35462 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | HTR1B | P28222 | 1/20 | 0.71 |
| ▸ | HTR2A | P28223 | 1/20 | 0.71 |
| ▸ | HTR2C | P28335 | 1/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.71 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.71 |
| ▸ | HTR2B | P41595 | 1/20 | 0.71 |
| ▸ | HTR5A | P47898 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630151 | 1.00 | HTR1A (0.71) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL8634782 | 1.00 | HTR1A (0.71) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL9451722 | 0.89 | DRD2 (0.71) | HTR1AHTR7DRD2DRD3 | |
| SCHEMBL9759874 | 0.88 | DRD2 (0.58) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL2022669 | 0.85 | DRD2 (0.68) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL14591373 | 0.84 | HTR1A (0.72) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL6542199 | 0.84 | HTR1A (0.72) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL9186743 | 0.83 | DRD2 (0.80) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL9451714 | 0.83 | HTR1A (0.71) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL8315435 | 0.83 | HTR1A (0.71) | HTR1AHTR7DRD2HTR1DDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389687-A | Selective antagonists of serotonin | ELI LILLY AND COMPANY (US) | 1995-02-14 | — | — | US | claimed |
| US-6331636-B1 | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, DIABETES, HYPERTENSION, IMPOTENCY, APPETITE CONTROL | THE UPJOHN COMPANY | 2001-12-18 | — | — | US | disclosed |
| EP-0579507-B1 | Isoxazole derivatives for the treatment of irritable bowel syndrome | LILLY CO ELI (US) | 2001-10-17 | — | — | EP | disclosed |
| EP-0712837-B1 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes | LILLY CO ELI (US) | 2000-10-25 | — | — | EP | disclosed |
| EP-0476016-B1 | CNS active 8-heterocyclyl-2-aminotetralin derivatives | UPJOHN CO (US) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683155-B1 | Tetrahydrobenz cd indoles with serotonin regulatory activity | LILLY CO ELI (US) | 1998-07-01 | — | — | EP | disclosed |
| US-5637624-A | ANTISEROTONIN AGENT | ELI LILLY AND COMPANY (US) | 1997-06-10 | — | — | US | disclosed |
| EP-0498590-B1 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes | LILLY CO ELI (US) | 1997-04-09 | — | — | EP | disclosed |
| EP-0471515-B1 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes and 3-aminothiochromanes | LILLY CO ELI (US) | 1997-03-05 | — | — | EP | disclosed |
| US-5594025-A | Method of inhibiting gastric acid secretion with 5-substituted-3-aminochromane | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0471515-A1 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes and 3-aminothiochromanes | ELI LILLY AND COMPANY (US) | 1992-02-19 | — | — | EP | disclosed |
| EP-0455510-A2 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | ELI LILLY AND COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |
| EP-0452390-A1 | HALO SUBSTITUTED AMINOTETRALINS. | UPJOHN CO (US) | 1991-10-23 | — | — | EP | disclosed |
| US-5047422-A | Treating A Disorder Of The Central Nervous System, Cardiovascular System Or Intestinal Tract | BAYER AKTIENGESELLSCHAFT (DE) | 1991-09-10 | — | — | US | disclosed |
| WO-1990015047-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |
| US-4968679-A | DISORDERS OF CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM OR INTESTINAL TRACT | BAYER AKTIENGESELLSCHAFT (DE) | 1990-11-06 | — | — | US | disclosed |
| EP-0385658-A1 | Ring-substituted 2-amino 1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes | ELI LILLY AND COMPANY (US) | 1990-09-05 | — | — | EP | disclosed |
| WO-1990007490-A1 | HALO SUBSTITUTED AMINOTETRALINS | THE UPJOHN COMPANY (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4873262-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, CARDIIOVASCULAR SYSTEM OR INTESTINAL TRACT | BAYER AKTIENGESELLSCHAFT (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0272534-A2 | 8-substituted 2-aminotetralins | BAYER AG (DE) | 1988-06-29 | — | — | EP | disclosed |