Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7768406 | 0.85 | CYP4F2 (0.53) | RECQLCYP4F2CYP4A11MAPK1ALDH1A1 | |
| SCHEMBL3548646 | 0.84 | TDP1 (0.44) | CDC7DBF4RECQLMEN1KMT2A | |
| SCHEMBL13653554 | 0.83 | CDC7 (0.49) | CDC7DBF4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7768376 | 0.82 | KDM4E (0.40) | CDC7DBF4MEN1KMT2AHTT | |
| SCHEMBL19915712 | 0.81 | MAPT (0.46) | MEN1KMT2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL31604246 | 0.81 | SMN1; SMN2 (0.47) | CDC7DBF4MEN1KMT2AHTT | |
| SCHEMBL9952026 | 0.81 | MEN1 (0.44) | CDC7DBF4MEN1KMT2AMAPK1 | |
| SCHEMBL15709664 | 0.81 | NOS1 (0.44) | CDC7DBF4MEN1KMT2AHTT | |
| SCHEMBL30163570 | 0.81 | MEN1 (0.44) | CDC7DBF4MEN1KMT2AMAPK1 | |
| SCHEMBL27037928 | 0.80 | NOS3 (0.50) | MEN1KMT2AMAPK1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846687-B1 | Pyrazoles as human non-pancreatic secretory phospholipase A2 inhibitors | LILLY CO ELI (US) | 2001-08-08 | — | — | EP | disclosed |
| US-5972972-A | FOR TREATMENT OF SEPTIC SHOCK, ADULT RESPIRATORY DISTRESS SYNDROME, PANCREATITIS, TRAUMA-INDUCED SHOCK, BRONCHIAL ASTHMA, ALLERGIC RHINITIS, RHEUMATOID ARTHRITIS | ELI LILLY AND COMPANY (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1998024437-A1 | PYRAZOLES AS HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-06-11 | — | — | WO | disclosed |
| EP-0846687-A1 | Pyrazoles as human non-pancreatic secretory phospholipase A2 inhibitors | ELI LILLY AND COMPANY (US) | 1998-06-10 | — | — | EP | disclosed |