SCHEMBL7763695

SCHEMBL7763695

CSc1ccc(NC(=O)C(NC(=O)C(CCCc2ccc(-c3ccccc3)cc2)CC(=O)O)C(C)(C)C)cc1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 20/20 0.73
MMP3 P08254 9/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7758573 0.85 MMP2 (0.71) MMP2MMP3
SCHEMBL7758741 0.85 MMP2 (0.69) MMP2MMP3
SCHEMBL7761531 0.81 MMP2 (0.72) MMP2MMP3
SCHEMBL7762285 0.81 MMP2 (0.82) MMP2MMP3
SCHEMBL7758482 0.80 MMP2 (0.62) MMP2MMP3
SCHEMBL7758796 0.78 MMP2 (0.59) MMP2MMP3
SCHEMBL7758509 0.77 MMP2 (0.71) MMP2MMP3
SCHEMBL7765051 0.77 MMP2 (0.60) MMP2MMP3
SCHEMBL7761249 0.77 MMP2 (0.60) MMP2MMP3
SCHEMBL7761563 0.76 MMP2 (0.60) MMP2MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1098662-A2 COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS WARNER-LAMBERT COMPANY (US) 2001-05-16 EP claimed
WO-2000004892-A2 COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS WARNER-LAMBERT COMPANY (US) 2000-02-03 WO claimed