SCHEMBL7761563

SCHEMBL7761563

CC(C)(C)[C@H](CO)NC(=O)C(CCCc1ccc(-c2ccccc2)cc1)CC(=O)O

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 20/20 0.60
MMP3 P08254 9/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7761567 1.00 MMP2 (0.60) MMP2MMP3
SCHEMBL6282661 0.90 MMP2 (0.69) MMP2MMP3
SCHEMBL6282657 0.90 MMP2 (0.69) MMP2MMP3
SCHEMBL7757916 0.88 MMP2 (0.53) MMP2MMP3
SCHEMBL7763157 0.82 MMP2 (0.49) MMP2MMP3
SCHEMBL7765152 0.82 MMP2 (0.55) MMP2MMP3
SCHEMBL7758600 0.80 MMP12 (0.60) MMP2MMP3
SCHEMBL7763746 0.79 MMP2 (0.49) MMP2MMP3
SCHEMBL7763742 0.79 MMP2 (0.49) MMP2MMP3
SCHEMBL7758551 0.78 MMP2 (0.51) MMP2MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1098662-A2 COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS WARNER-LAMBERT COMPANY (US) 2001-05-16 EP claimed
WO-2000004892-A2 COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS WARNER-LAMBERT COMPANY (US) 2000-02-03 WO claimed