SCHEMBL77641

SCHEMBL77641

Nc1ncnc2c1ncn2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)O)O1

nearest known ligand 0.81

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.81
P2RY1 P47900 5/20 0.74
ENPP1 P22413 3/20 0.74
P2RX1 P51575 4/20 0.68
P2RX3 P56373 4/20 0.68
P2RX2 Q9UBL9 2/20 0.68
P2RX4 Q99571 3/20 0.66
P2RY2 P41231 2/20 0.66
SRC P12931 1/20 0.66
ALDH1A1 P00352 1/20 0.66
SMN1; SMN2 Q16637 1/20 0.66
DTYMK P23919 2/20 0.65
RNASEL Q05823 1/20 0.63
MACROD2 A1Z1Q3 1/20 0.61
SIRT6 Q8N6T7 1/20 0.61
MACROD1 Q9BQ69 1/20 0.61
TRPM2 O94759 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31211719 1.00 POLB (0.81) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL2508784 1.00 POLB (0.81) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL29352481 1.00 POLB (0.81) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL889289 0.99 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL703733 0.99 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL18785117 0.99 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL14471000 0.99 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL5044161 0.99 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL78250 0.99 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL29350133 0.99 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1590 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120005959-A Method for synthesizing deoxynucleoside triphosphate by enzyme method 上海合全药物研发有限公司 2025-05-16 CN claimed
WO-2025072741-A1 PRESERVATIVES FOR MOLECULAR SAMPLE ANALYSIS WITH SAMPLE COLLECTION DEVICES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-04-03 WO claimed
US-12145951-B2 Inorganic-organic hybrid compounds including organic platinum-containing anions, for use in medicine KARLSRUHER INSTITUT FUR TECHNOLOGIE (DE) 2024-11-19 US claimed
CN-114940985-B Protein with deoxyadenosine diphosphate kinase and acetate kinase activities and application thereof 苏州酶泰生物科技有限公司 2024-03-19 CN claimed
CN-114903028-B Erythrocyte cryoprotectant and preparation method and application thereof 华南理工大学 2023-10-17 CN claimed
CN-114940985-A Protein with activity of deoxyadenosine diphosphate kinase and acetate kinase and application thereof 苏州酶泰生物科技有限公司 2022-08-26 CN claimed
CN-114903028-A Erythrocyte cryoprotectant and preparation method and application thereof 华南理工大学 2022-08-16 CN claimed
WO-2022127326-A1 PROTEIN AND MULTI-STAGE POROUS METAL-ORGANIC FRAMEWORK COMPLEX, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 华南理工大学 2022-06-23 WO claimed
US-20220136040-A1 USING TETHERED ENZYMES TO DETECT NUCLEIC ACIDS CORNELL UNIVERSITY 2022-05-05 US claimed
EP-3931346-A1 USING TETHERED ENZYMES TO DETECT NUCLEIC ACIDS Cornell University (US) 2022-01-05 EP claimed
EP-0918882-A1 REGULATION OF APOPTOSIS AND IN VITRO MODEL FOR STUDIES THEREOF EMORY UNIVERSITY (US) 1999-06-02 EP claimed
US-5874272-A ISOLATED AND PURIFIED PROTEIN ENZYME OBTAINED FROM THE GENUS ESCHERICHIA, HAVING PHYSICOCHEMICAL PROPERTIES; CATALYZING THE REACTION OF FORMING 5'-INOSINIC ACID FROM INOSINE, FORMING 5'-GUANYLIC ACID FROM GUANOSINE KYOWA HAKKO KOGYO CO., LTD. (JP) 1999-02-23 US claimed
WO-1998002579-A9 REGULATION OF APOPTOSIS AND IN VITRO MODEL FOR STUDIES THEREOF 1998-04-30 WO claimed
WO-1998002579-A1 REGULATION OF APOPTOSIS AND IN VITRO MODEL FOR STUDIES THEREOF EMORY UNIVERSITY (US) 1998-01-22 WO claimed
EP-0458971-B1 INOSINE GUANOSINE KINASE KYOWA HAKKO KOGYO KK (JP) 1996-01-03 EP claimed
WO-1994029331-A1 NICOTINAMIDE RIBONUCLEOTIDE ISOSTERS, ISOSTERIC NAD ANALOGUES. THEIR SYNTHESES AND USE IN TREATMENTS OF ALCOHOLISM AND NEOPLASTIC DISEASES SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1994-12-22 WO claimed
EP-0577266-A2 Method for preparing (gamma-32p) labeled nucleotides by enzymatic conversion of dihydroxyacetone phosphate to 3-phosphoglycerate ICN BIOMEDICALS INC. (US) 1994-01-05 EP claimed
EP-0458971-A1 INOSINE GUANOSINE KINASE KYOWA HAKKO KOGYO CO., LTD. (JP) 1991-12-04 EP claimed
US-4577012-A ABSORPTION ON ACTIVATED CARBON, ELUTION WITH ALKALI HYDROXIDE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1986-03-18 US claimed
US-4209589-A Enzymatic process for preparing [γ-32 P]-labeled nucleotides VANDERBILT UNIVERSITY (US) 1980-06-24 US claimed