SCHEMBL78250

SCHEMBL78250

Nc1ncnc2c1ncn2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O1

nearest known ligand 0.80

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.80
P2RY1 P47900 6/20 0.73
ENPP1 P22413 3/20 0.73
P2RX1 P51575 3/20 0.70
P2RX3 P56373 3/20 0.70
P2RX2 Q9UBL9 2/20 0.70
P2RY2 P41231 2/20 0.67
P2RX4 Q99571 2/20 0.67
SRC P12931 1/20 0.67
ALDH1A1 P00352 1/20 0.67
SMN1; SMN2 Q16637 1/20 0.67
DTYMK P23919 2/20 0.66
RNASEL Q05823 1/20 0.65
MACROD2 A1Z1Q3 1/20 0.63
SIRT6 Q8N6T7 1/20 0.63
MACROD1 Q9BQ69 1/20 0.63
TRPM2 O94759 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5044161 1.00 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL29350133 1.00 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL3030614 1.00 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL29702495 1.00 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL14471000 1.00 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL18785117 1.00 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL889289 1.00 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL703733 1.00 POLB (0.80) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL31211719 0.99 POLB (0.81) POLBP2RY1ENPP1P2RX1P2RX3
SCHEMBL2508784 0.99 POLB (0.81) POLBP2RY1ENPP1P2RX1P2RX3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 9746 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146272-A1 ENZYMATIC SYNTHESIS OF MODIFIED NUCLEOSIDE TRIPHOSPHATE ANALOGUES ILLUMINA, INC. (US) 2026-05-28 US claimed
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
CN-122060854-A Long fragment PCR amplification reaction liquid and application thereof 杭州艾迪康医学检验中心有限公司 2026-05-19 CN claimed
EP-4729633-A2 METHODS FOR DETECTING NUCLEIC ACID VARIANTS Guardant Health, Inc. (US) 2026-04-22 EP claimed
EP-4724611-A2 METHOD FOR RAPIDLY AND ACCURATELY DETECTING HOP LATENT VIROID RNA Colorado Genomics LLC (US) 2026-04-15 EP claimed
EP-4368725-B1 A METHOD FOR THE ISOLATION OF DOUBLE-STRAND BREAKS UNIV COLLEGE CARDIFF CONSULTANTS LTD (GB) 2026-03-04 EP claimed
EP-3931346-B1 USING TETHERED ENZYMES TO DETECT NUCLEIC ACIDS UNIV CORNELL (US) 2026-02-25 EP claimed
EP-4291679-B1 METHODS FOR DETECTING NUCLEIC ACID VARIANTS GUARDANT HEALTH INC (US) 2026-02-04 EP claimed
EP-4660319-A1 METHOD FOR SEQUENCING OF A DNA STRAND Robert Bosch GmbH (DE) 2025-12-10 EP claimed
US-20250369027-A1 SUBSTRATE CLEAVAGE FOR NUCLEIC ACID SYNTHESIS TWIST BIOSCIENCE CORP (US) 2025-12-04 US claimed
EP-0458971-A1 INOSINE GUANOSINE KINASE KYOWA HAKKO KOGYO CO., LTD. (JP) 1991-12-04 EP claimed
US-5024934-A Incubating a mixture of cell samples, dna polymerase and oligonucleotide primers to facilitate duplication and analyzing THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1991-06-18 US claimed
WO-1990010698-A1 DIRECTIONAL CLONING ZYMOGENETICS, INC. (US) 1990-09-20 WO claimed
CN-1039899-A A kind of method that detects tumour with iodine labeling NAVY MEDICAL SCIENCE INST PLA (CN) 1990-02-21 CN claimed
WO-1989008717-A1 DETECTION OF MINIMAL NUMBERS OF NEOPLASTIC CELLS CARRYING DNA TRANSLOCATIONS BY DNA SEQUENCE AMPLIFICATION BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1989-09-21 WO claimed
US-4577012-A ABSORPTION ON ACTIVATED CARBON, ELUTION WITH ALKALI HYDROXIDE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1986-03-18 US claimed
US-4572894-A USING AMINOACYL-TRNA SYNTHETASE AS CONDENSING AGENT Imahori, Kazutomo (JP) 1986-02-25 US claimed
EP-0086053-B1 PROCESS FOR SYNTHESIZING PEPTIDES OR PEPTIDE DERIVATIVES Imahori, Kazutomo (JP) 1986-01-02 EP claimed
EP-0086053-A1 Process for synthesizing peptides or peptide derivatives Imahori, Kazutomo (JP) 1983-08-17 EP claimed
US-4264729-A Method and reagent for detecting cancerigenic and anticancerous substances BELJANSKI MIRKO 1981-04-28 US claimed