Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 15/20 | 1.00 |
| ▸ | TNKS2 | Q9H2K2 | 13/20 | 1.00 |
| ▸ | PARP1 | P09874 | 7/20 | 1.00 |
| ▸ | GUSB | P08236 | 6/20 | 0.72 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.72 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.72 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | CASP3 | P42574 | 1/20 | 0.71 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.71 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.69 |
| ▸ | WNT3A | P56704 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29764113 | 1.00 | TNKS (1.00) | TNKSTNKS2PARP1GUSBPARP2 | |
| SCHEMBL6885282 | 0.92 | TNKS (0.93) | TNKSTNKS2PARP1GUSBPARP2 | |
| SCHEMBL6124189 | 0.88 | TNKS (0.93) | TNKSTNKS2PARP1GUSBPARP2 | |
| SCHEMBL29592833 | 0.88 | TNKS (1.00) | TNKSTNKS2PARP1GUSBPARP2 | |
| SCHEMBL258433 | 0.88 | TNKS (1.00) | TNKSTNKS2PARP1GUSBPARP2 | |
| Hydrochloric Acid SCHEMBL31529601 | 0.86 | TNKS (0.96) | TNKSTNKS2PARP1GUSBPARP2 | |
| SCHEMBL28639676 | 0.86 | NPC1 (0.78) | TNKSTNKS2PARP1GUSBPARP2 | |
| SCHEMBL28008970 | 0.84 | TNKS (0.73) | TNKSTNKS2PARP1GUSBPARP2 | |
| SCHEMBL8618982 | 0.84 | TNKS (1.00) | TNKSTNKS2PARP1GUSBPARP2 | |
| SCHEMBL15775876 | 0.84 | TNKS (0.78) | TNKSTNKS2PARP1GUSBPARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4431440-A | 2-/4-METHYLPHENYL/-4-3H-QUINAZOLINES AS HERBICIDES AND PLANT GROWTH REGULATORS; CEREALS | AMERICAN CYANAMID COMPANY (US) | 1984-02-14 | — | — | US | claimed |
| EP-0058822-A1 | Method to alter or control the development and/or life cycle of various plant species | AMERICAN CYANAMID COMPANY (US) | 1982-09-01 | — | — | EP | claimed |
| JP-8143586-A | — | — | None | — | — | JP | disclosed |
| CN-115650924-B | Green synthesis method of quinazolinone | 山东华泰新材料技术研发有限公司 | 2024-08-20 | — | — | CN | disclosed |
| CN-115710251-B | Medullary differentiation factor 88 inhibitor and preparation method and application thereof | 杭州医学院 | 2024-05-28 | — | — | CN | disclosed |
| CN-117924190-A | 2-Phenyl-4-amino quinazoline compound or pharmaceutically acceptable salt thereof, and preparation method and application thereof | 重庆医科大学 | 2024-04-26 | — | — | CN | disclosed |
| CN-115010671-B | One-step synthesis method of 2-substituted quinazolinone | 江苏大学 | 2023-10-10 | — | — | CN | disclosed |
| CN-111777564-B | Method for synthesizing quinazolinone compound by photocatalytic alcohol oxidation in aqueous phase | 许昌学院 | 2023-07-14 | — | — | CN | disclosed |
| CN-113563272-B | Preparation method of 2-phenylquinazolinone compound | 三峡大学 | 2023-03-10 | — | — | CN | disclosed |
| CN-115710251-A | Myeloid differentiation factor 88 inhibitor and preparation method and application thereof | 杭州医学院 | 2023-02-24 | — | — | CN | disclosed |
| CN-115650924-A | Green synthesis method of quinazolinone | 上海橡实化学有限公司 | 2023-01-31 | — | — | CN | disclosed |
| US-20140256754-A1 | QUINAZOLINES AS B-GLUCURONIDASE NOVEL INHIBITORS | CHOUDHARY MUHAMMAD IQBAL (PK) | 2014-09-11 | — | — | US | disclosed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |
| EP-0749974-B1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-06-27 | — | — | EP | disclosed |
| US-5798344-A | TREATING DIABETES, HYPERLIPIDEMIA | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-08-25 | — | — | US | disclosed |
| EP-0749974-A1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-12-27 | — | — | EP | disclosed |
| JP-H08143586-A | PHOSPHONIC ACID DIESTER DERIVATIVE | OTSUKA PHARMACEUT FACTORY INC | 1996-06-04 | — | — | JP | disclosed |
| US-4431440-A | 2-/4-METHYLPHENYL/-4-3H-QUINAZOLINES AS HERBICIDES AND PLANT GROWTH REGULATORS; CEREALS | AMERICAN CYANAMID COMPANY (US) | 1984-02-14 | — | — | US | disclosed |
| EP-0058822-A1 | Method to alter or control the development and/or life cycle of various plant species | AMERICAN CYANAMID COMPANY (US) | 1982-09-01 | — | — | EP | disclosed |
| US-3998951-A | Substituted 2-arylquinazolines as fungicides | FMC CORPORATION (US) | 1976-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256754-A1 | QUINAZOLINES AS B-GLUCURONIDASE NOVEL INHIBITORS | GUSB, GBA3, GAA | TNKS 1726/4885TNKS2 1674/4885PARP1 2165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.