Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7767039 | 0.92 | SMN1; SMN2 (0.46) | SMN1; SMN2PDE4DLMNANAMPTKDM4E | |
| SCHEMBL7146644 | 0.92 | SMN1; SMN2 (0.53) | SMN1; SMN2PDE4DLMNANPC1RAB9A | |
| SCHEMBL7767933 | 0.91 | SMN1; SMN2 (0.44) | SMN1; SMN2PDE4DLMNANAMPTNPC1 | |
| SCHEMBL7151689 | 0.90 | SMN1; SMN2 (0.43) | SMN1; SMN2PDE4DLMNANAMPTNPC1 | |
| SCHEMBL7766251 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2PDE4DLMNANAMPTMAPT | |
| SCHEMBL7762515 | 0.87 | SMN1; SMN2 (0.45) | SMN1; SMN2PDE4DLMNANAMPTNPC1 | |
| SCHEMBL7762520 | 0.86 | JAK2 (0.48) | SMN1; SMN2PDE4DNPC1RAB9AKDM4E | |
| SCHEMBL7762456 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2PDE4DMAPTKMT2AJAK1 | |
| SCHEMBL6871450 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2PDE4DLMNAKDM4EALDH1A1 | |
| SCHEMBL7767942 | 0.85 | SMN1; SMN2 (0.41) | SMN1; SMN2PDE4DLMNANAMPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |