Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7044503 | 0.92 | HPGD (0.43) | JAK2SMN1; SMN2PDE4DKDM4EHPGD | |
| SCHEMBL7766251 | 0.92 | SMN1; SMN2 (0.47) | JAK2SMN1; SMN2PDE4DHPGDMAPK1 | |
| SCHEMBL7762456 | 0.90 | SMN1; SMN2 (0.45) | JAK2SMN1; SMN2PDE4DKMT2AMAPT | |
| SCHEMBL6871450 | 0.90 | SMN1; SMN2 (0.45) | JAK2SMN1; SMN2PDE4DKDM4EHPGD | |
| SCHEMBL7146644 | 0.90 | SMN1; SMN2 (0.53) | SMN1; SMN2PDE4DKDM4ENPC1RAB9A | |
| SCHEMBL7762663 | 0.89 | PDE4D (0.57) | SMN1; SMN2PDE4DNPC1MAPTFYN | |
| SCHEMBL7766283 | 0.89 | FYN (0.47) | SMN1; SMN2PDE4DKDM4EFYN | |
| SCHEMBL7765386 | 0.88 | JAK2 (0.45) | JAK2SMN1; SMN2PDE4DKDM4EHPGD | |
| SCHEMBL7142931 | 0.86 | PDE4D (0.51) | SMN1; SMN2PDE4DKDM4ENPC1RAB9A | |
| SCHEMBL7765412 | 0.86 | SMN1; SMN2 (0.47) | SMN1; SMN2PDE4DKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |