Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7765412 | 0.92 | SMN1; SMN2 (0.47) | SMN1; SMN2PDE4DKMT2AJAK1KDM4E | |
| SCHEMBL7146644 | 0.90 | SMN1; SMN2 (0.53) | SMN1; SMN2PDE4DKMT2AKDM4EALDH1A1 | |
| SCHEMBL7762456 | 0.89 | SMN1; SMN2 (0.45) | SMN1; SMN2PDE4DKMT2AJAK2JAK1 | |
| SCHEMBL7767933 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2PDE4DKMT2AJAK1ALDH1A1 | |
| SCHEMBL7151689 | 0.88 | SMN1; SMN2 (0.43) | SMN1; SMN2PDE4DKMT2AJAK1KDM4E | |
| SCHEMBL7044324 | 0.86 | KMT2A (0.46) | SMN1; SMN2KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL7762515 | 0.86 | SMN1; SMN2 (0.45) | SMN1; SMN2PDE4DKMT2AKDM4EALDH1A1 | |
| SCHEMBL7766248 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2PDE4DKMT2AJAK1KDM4E | |
| SCHEMBL7766251 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2PDE4DJAK2HPGDLMNA | |
| SCHEMBL7762520 | 0.84 | JAK2 (0.48) | SMN1; SMN2PDE4DKMT2AJAK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |