Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7766834 | 0.89 | CYP2C19 (0.40) | MTNR1ACYP3A4TSHRCYP2C19EHMT2 | |
| SCHEMBL7761971 | 0.86 | TP53 (0.42) | CYP3A4TSHRCYP2C19TP53GAA | |
| SCHEMBL7762203 | 0.83 | HDAC6 (0.44) | MTNR1ACYP3A4TSHRMEN1KMT2A | |
| SCHEMBL7764939 | 0.81 | EHMT2 (0.44) | CYP3A4TSHRCYP2C19EHMT2GAA | |
| SCHEMBL7762178 | 0.77 | CRBN (0.46) | CYP3A4TSHRCYP2C19EHMT2GAA | |
| SCHEMBL7765837 | 0.73 | EHMT2 (0.39) | CYP3A4TSHRCYP2C19EHMT2SMO | |
| SCHEMBL7764862 | 0.71 | EHMT2 (0.47) | CYP3A4TSHRCYP2C19EHMT2SMO | |
| SCHEMBL9736566 | 0.70 | EHMT2 (0.41) | TSHREHMT2BRD4TP53GAA | |
| SCHEMBL9736877 | 0.70 | EHMT2 (0.41) | TSHREHMT2BRD4TP53GAA | |
| SCHEMBL7762198 | 0.69 | CRBN (0.39) | CYP3A4TSHRCYP2C19EHMT2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639566-B1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO LTD (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-5461158-A | Immunodeficiency and autoimmune diseases | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| EP-0639566-A1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-02-22 | — | — | EP | disclosed |