SCHEMBL7765864

SCHEMBL7765864

CO[Si](CCCBr)(OC)Oc1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CA4 P22748 1/20 0.35
KCNA3 P22001 1/20 0.33
LTA4H P09960 2/20 0.31
KCNH2 Q12809 2/20 0.31
HTR1B P28222 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.30
DRD2 P14416 1/20 0.30
DRD4 P21917 1/20 0.30
DRD3 P35462 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3923681 0.89 KCNA3 (0.38) CA4KCNA3LTA4HKCNH2HTR1B
SCHEMBL19816665 0.84 LTA4H (0.43) CA4KCNA3LTA4HKCNH2DRD2
SCHEMBL3355478 0.82 HDAC3 (0.43) CA4KCNA3LTA4HHTR1BL3MBTL1
SCHEMBL19816823 0.82 LTA4H (0.43) CA4LTA4HKCNH2DRD2DRD3
SCHEMBL10863992 0.82 TAAR1 (0.38) CA4LTA4HKCNH2
SCHEMBL25395317 0.81 LTA4H (0.42) LTA4HKCNH2DRD2DRD3
SCHEMBL31187713 0.81 LTA4H (0.42) LTA4HKCNH2DRD2DRD3
SCHEMBL19816793 0.81 LTA4H (0.42) LTA4HKCNH2DRD2DRD3
Toluene SCHEMBL22494190 0.80 ACHE (0.41) CA4L3MBTL1DRD2DRD4DRD3
SCHEMBL1608986 0.80 LTA4H (0.43) CA4KCNA3LTA4HKCNH2DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0705838-B1 Process for the preparation of silane polysulfides CROMPTON CORP (US) 2001-05-23 EP disclosed
US-5596116-A Process for the preparation of silane polysulfides OSI SPECIALTIES, INC. (US) 1997-01-21 US disclosed
EP-0705838-A2 Process for the preparation of silane polysulfides OSi SPECIALTIES, INC. (US) 1996-04-10 EP disclosed
US-5489701-A REACTING SULFUR AND A HALOHYDROCARBYLALKOXYSILANE WITH THE REACTION PRODUCT OF HYDROGEN SULFIDE GAS AND A METAL ALKOXIDE SOLUTION OSI SPECIALTIES, INC. (US) 1996-02-06 US disclosed
US-5466848-A Sulfiding sodium ethoxide with hydrogen sulfide to make sodium sulfide; reacting with sulfur to tetrasulfide; reacting with halohydrocarbylalkoxysilane OSI SPECIALTIES, INC. (US) 1995-11-14 US disclosed
US-5399739-A Method of making sulfur-containing organosilanes WRIGHT CHEMICAL CORPORATION (US) 1995-03-21 US disclosed
US-4507490-A SULFIDING A HALOALKYLORGANOSILANE DEGUSSA AKTIENGESELLSCHAFT (DE) 1985-03-26 US disclosed
US-4129585-A NO FORMATION OF HYDROGEN SULFIDE DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) 1978-12-12 US disclosed