Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7767210 | 1.00 | TAS1R3 (0.38) | TAS1R3TAS1R1TAS1R2TSHRALDH1A1 | |
| SCHEMBL310647 | 0.78 | TAS1R3 (0.37) | TAS1R3TAS1R1TAS1R2TSHRALDH1A1 | |
| SCHEMBL310648 | 0.78 | TAS1R3 (0.37) | TAS1R3TAS1R1TAS1R2TSHRALDH1A1 | |
| SCHEMBL5070752 | 0.69 | TAS1R3 (0.38) | TAS1R3TAS1R1TAS1R2TSHRALDH1A1 | |
| SCHEMBL5070753 | 0.69 | TAS1R3 (0.38) | TAS1R3TAS1R1TAS1R2TSHRALDH1A1 | |
| SCHEMBL1554603 | 0.68 | GPR35 (0.42) | TAS1R3TAS1R1TAS1R2TSHRALDH1A1 | |
| SCHEMBL1554601 | 0.68 | GPR35 (0.42) | TAS1R3TAS1R1TAS1R2TSHRALDH1A1 | |
| SCHEMBL10665640 | 0.67 | TSHR (0.44) | TAS1R3TAS1R1TAS1R2TSHRALDH1A1 | |
| SCHEMBL11418791 | 0.67 | TSHR (0.63) | TAS1R3TAS1R1TAS1R2TSHRALDH1A1 | |
| SCHEMBL7772728 | 0.67 | TSHR (0.44) | TAS1R3TAS1R1TAS1R2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0879230-B1 | OPTICALLY ACTIVE PHENYL PYRIMIDINE DERIVATIVE AS ANALGESIC AGENT | GLAXO GROUP LTD (GB) | 2001-07-25 | — | — | EP | disclosed |
| US-6124308-A | ANALGESICS, ANTICONVULSANTS, TREATING IRRITABLE BOWEL SYNDROME OR BIPOLAR DISORDER | GLAXO WELLCOME INC. (US) | 2000-09-26 | — | — | US | disclosed |