Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8656770 | 0.91 | CA12 (0.68) | KMT2AMAPTMEN1HPGDSMN1; SMN2 | |
| SCHEMBL4570567 | 0.91 | KMT2A (0.75) | KMT2AMAPTMEN1CASP3TRPV1 | |
| SCHEMBL62862 | 0.91 | KMT2A (0.75) | KMT2AMAPTMEN1CASP3TRPV1 | |
| Hydrochloric Acid SCHEMBL28579442 | 0.89 | KMT2A (0.73) | KMT2AMAPTMEN1CASP3TRPV1 | |
| SCHEMBL11603129 | 0.87 | MAPT (0.55) | KMT2AMAPTMEN1CASP3TRPV1 | |
| SCHEMBL7365076 | 0.86 | KMT2A (0.69) | KMT2AMAPTMEN1CASP3TRPV1 | |
| SCHEMBL9923544 | 0.86 | CA12 (0.61) | KMT2AMAPTHPGDALDH1A1CA12 | |
| Ethylene Glycol SCHEMBL6701397 | 0.86 | CA12 (0.61) | MAPTHPGDSMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL9170741 | 0.85 | MEN1 (0.58) | KMT2AMAPTMEN1CASP3TRPV1 | |
| SCHEMBL19898170 | 0.85 | TDP1 (0.56) | KMT2AMAPTMEN1CASP3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846687-B1 | Pyrazoles as human non-pancreatic secretory phospholipase A2 inhibitors | LILLY CO ELI (US) | 2001-08-08 | — | — | EP | disclosed |
| US-5972972-A | FOR TREATMENT OF SEPTIC SHOCK, ADULT RESPIRATORY DISTRESS SYNDROME, PANCREATITIS, TRAUMA-INDUCED SHOCK, BRONCHIAL ASTHMA, ALLERGIC RHINITIS, RHEUMATOID ARTHRITIS | ELI LILLY AND COMPANY (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1998024437-A1 | PYRAZOLES AS HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-06-11 | — | — | WO | disclosed |
| EP-0846687-A1 | Pyrazoles as human non-pancreatic secretory phospholipase A2 inhibitors | ELI LILLY AND COMPANY (US) | 1998-06-10 | — | — | EP | disclosed |