Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.96 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.96 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.96 |
| ▸ | HPGD | P15428 | 7/20 | 0.96 |
| ▸ | ESR1 | P03372 | 1/20 | 0.96 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.96 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.96 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 1/20 | 0.96 |
| ▸ | GGT1 | P19440 | 1/20 | 0.96 |
| ▸ | BLM | P54132 | 1/20 | 0.96 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.96 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.96 |
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspirin SCHEMBL11692311 | 1.00 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL1353 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL10456693 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL29350479 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL1331740 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL7580 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL26229 | 0.96 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL21722099 | 0.96 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL4303603 | 0.96 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL21488922 | 0.96 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109925252-A | A kind of spray for capableing of nourishes rough skin | 新昌县祥顺物资有限公司 | 2019-06-25 | — | — | CN | claimed |
| CN-106729644-A | A kind of gentle multiple-effect ectylotic and preparation method thereof | 郑州兰茜生物工程有限公司 | 2017-05-31 | — | — | CN | claimed |
| CN-106389139-A | Acne-removing, mark-eliminating and skin-protecting multifunctional preparation and preparation method thereof | 河南工业大学 | 2017-02-15 | — | — | CN | claimed |
| CN-102578144-B | Product and method for generating peracetic acid | BEIJING KANGFULE TECHNOLOGY CO LTD | 2014-04-02 | — | — | CN | claimed |
| CN-102578144-A | Product and method for generating peracetic acid | BEIJING KANGFULE TECHNOLOGY CO LTD | 2012-07-18 | — | — | CN | claimed |
| EP-1104236-A1 | TRANSDERMALLY DELIVERED ASPIRIN | Galat, Alexander (US) | 2001-06-06 | — | — | EP | claimed |
| WO-2000076315-A1 | TRANSDERMALLY DELIVERED ASPIRIN | GALAT ALEXANDER (US) | 2000-12-21 | — | — | WO | claimed |
| CN-109925252-A | A kind of spray for capableing of nourishes rough skin | 新昌县祥顺物资有限公司 | 2019-06-25 | — | — | CN | disclosed |
| CN-109925252-A | A kind of spray for capableing of nourishes rough skin | 新昌县祥顺物资有限公司 | 2019-06-25 | — | — | CN | disclosed |
| CN-103271083-B | Multi-functional ionic liquid compositions | 阿拉巴马大学 | 2017-08-11 | — | — | CN | disclosed |
| CN-106729644-A | A kind of gentle multiple-effect ectylotic and preparation method thereof | 郑州兰茜生物工程有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106389139-A | Acne-removing, mark-eliminating and skin-protecting multifunctional preparation and preparation method thereof | 河南工业大学 | 2017-02-15 | — | — | CN | disclosed |
| CN-104144703-A | METHOD FOR IMPROVING WATER SOLUBILITY OF SLIGHTLY SOLUBLE SUBSTANCE | SANGI KK | 2014-11-12 | — | — | CN | disclosed |
| CN-102578144-B | Product and method for generating peracetic acid | BEIJING KANGFULE TECHNOLOGY CO LTD | 2014-04-02 | — | — | CN | disclosed |
| CN-102573912-B | Method for improving water solubility of poorly soluble substance | SANGI KK | 2014-01-01 | — | — | CN | disclosed |
| CN-103492417-A | Tumor-specific antibodies and uses thereof | UNIV NORTH CAROLINA | 2014-01-01 | — | — | CN | disclosed |
| CN-102578144-A | Product and method for generating peracetic acid | BEIJING KANGFULE TECHNOLOGY CO LTD | 2012-07-18 | — | — | CN | disclosed |
| CN-102573912-A | Method for improving water solubility of poorly soluble substance | SANGI KK | 2012-07-11 | — | — | CN | disclosed |
| US-4004002-A | PREVENT GASTRIC IRRITATION | A. H. ROBINS COMPANY, INCORPORATED (US) | 1977-01-18 | — | — | US | disclosed |