Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 7/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.50 |
| ▸ | HTR2A | P28223 | 5/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.50 |
| ▸ | HRH1 | P35367 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7796036 | 0.99 | LMNA (0.52) | LMNAMAPTCYP3A4CYP2D6FAAH | |
| Hydrochloric Acid SCHEMBL7920769 | 0.99 | LMNA (0.52) | LMNAMAPTCYP3A4CYP2D6FAAH | |
| SCHEMBL7794410 | 0.91 | LMNA (0.52) | LMNAMAPTCYP3A4CYP2D6FAAH | |
| SCHEMBL7773850 | 0.91 | MAPT (0.67) | LMNAMAPTCYP3A4CYP2D6FAAH | |
| Hydrochloric Acid SCHEMBL7797695 | 0.90 | MAPT (0.66) | LMNAMAPTCYP3A4CYP2D6FAAH | |
| Hydrochloric Acid SCHEMBL7794406 | 0.90 | LMNA (0.51) | LMNAMAPTCYP3A4CYP2D6FAAH | |
| SCHEMBL7794415 | 0.89 | DRD3 (0.53) | LMNAMAPTCYP3A4CYP2D6FAAH | |
| SCHEMBL7771969 | 0.88 | LMNA (0.52) | LMNAMAPTCYP3A4CYP2D6FAAH | |
| Hydrochloric Acid SCHEMBL9602731 | 0.88 | MEN1 (0.52) | LMNAMAPTCYP3A4CYP2D6FAAH | |
| Hydrochloric Acid SCHEMBL7794427 | 0.87 | LMNA (0.51) | LMNAMAPTCYP3A4CYP2D6FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658910-A | TREATING MENTAL DISORDERS | PHARMACIA AB (SE) | 1997-08-19 | — | — | US | claimed |
| EP-0673368-B1 | NOVEL NICOTINIC ACID ESTERS | BIOVITRUM AB (SE) | 2001-11-28 | — | — | EP | disclosed |
| EP-1120410-A1 | Nicotinic acid esters useful as CNS agents and having affinity for 5-HT receptors | Pharmacia AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| US-6221858-B1 | Pyridyl-and pyrimidyl-piperazines in the treatment of substance abuse disorders | PHARMACIA & UPJOHN AB (SE) | 2001-04-24 | — | — | US | disclosed |
| EP-0637242-B1 | AGENTS FOR TREATING SUBSTANCE ABUSE DISORDERS | PHARMACIA & UPJOHN AB (SE) | 1999-09-15 | — | — | EP | disclosed |
| US-5658910-A | TREATING MENTAL DISORDERS | PHARMACIA AB (SE) | 1997-08-19 | — | — | US | disclosed |
| US-5565455-A | ADMINISTERING A BISPHENYLALKYLPIPERAZINE TO COMBAT WITHDRAWAL SYMPTOMS | PHARMACIA AB (SE) | 1996-10-15 | — | — | US | disclosed |
| EP-0673368-A1 | NOVEL NICOTINIC ACID ESTERS | Pharmacia & Upjohn Aktiebolag (SE) | 1995-09-27 | — | — | EP | disclosed |
| EP-0637242-A1 | AGENTS FOR TREATING SUBSTANCE ABUSE DISORDERS | Kabi Pharmacia AB (SE) | 1995-02-08 | — | — | EP | disclosed |
| WO-1994000434-A1 | NOVEL NICOTINIC ACID ESTERS | KABI PHARMACIA AB (SE) | 1994-01-06 | — | — | WO | disclosed |
| WO-1993020821-A1 | AGENTS FOR TREATING SUBSTANCE ABUSE DISORDERS | KABI PHARMACIA AB (SE) | 1993-10-28 | — | — | WO | disclosed |