Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11889487 | 0.78 | HRH3 (0.46) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL10389385 | 0.76 | LMNA (0.34) | TSHRL3MBTL1 | |
| SCHEMBL5975144 | 0.76 | HRH3 (0.41) | HRH3MAPTMAPK1ALDH1A1L3MBTL1 | |
| SCHEMBL10892811 | 0.74 | MAPT (0.54) | MAPTSMN1; SMN2ATMALDH1A1TSHR | |
| SCHEMBL9530673 | 0.73 | HRH3 (0.50) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL3556893 | 0.72 | MAPT (0.52) | MAPTSMN1; SMN2ATMALDH1A1TSHR | |
| SCHEMBL11117426 | 0.72 | MAPT (0.52) | MAPTSMN1; SMN2ATMALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL30101250 | 0.72 | HRH3 (0.43) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL7769335 | 0.72 | HRH3 (0.52) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL28778483 | 0.71 | HRH3 (0.47) | HRH3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265575-B1 | THROMBIN INHIBITORS | ELI LILLY AND COMPANY | 2001-07-24 | — | — | US | disclosed |
| US-6251921-B1 | ADMINISTERING THROMBIN INHIBITING DIAMINE COMPOUND TO MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-6025382-A | Antithrombotic diamines | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |