Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11179160 | 0.88 | HRH3 (0.39) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL5489928 | 0.88 | HRH3 (0.39) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL10846104 | 0.86 | HRH3 (0.36) | HRH3MAPTALDH1A1TSHRLMNA | |
| SCHEMBL7768226 | 0.78 | HRH3 (0.43) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL28884650 | 0.78 | KEAP1 (0.46) | HRH3CYP1A2MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5248220 | 0.74 | FDPS (0.31) | — | |
| SCHEMBL28778483 | 0.73 | HRH3 (0.47) | HRH3MAPTHRH1 | |
| SCHEMBL643894 | 0.72 | HRH3 (0.44) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL22077060 | 0.72 | HRH3 (0.50) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL2099926 | 0.72 | HRH3 (0.40) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971604-B1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC (US) | 2012-08-01 | — | — | EP | disclosed |