Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 9/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | EDNRB | P24530 | 2/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7764513 | 0.83 | EDNRA (0.67) | EDNRAMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL7772536 | 0.83 | EDNRA (0.67) | EDNRAMEN1KMT2AALDH1A1EDNRB | |
| SCHEMBL8392571 | 0.83 | EDNRA (0.67) | EDNRAEDNRBHCRTR1TSHRPGR | |
| SCHEMBL7770323 | 0.83 | EDNRA (0.69) | EDNRAKMT2AMAPTALDH1A1EDNRB | |
| SCHEMBL8390507 | 0.83 | EDNRA (0.66) | EDNRAALDH1A1EDNRBHCRTR1TSHR | |
| SCHEMBL8890035 | 0.81 | EDNRA (1.00) | EDNRATSHRKDM4ENSD2HSD17B10 | |
| SCHEMBL7770284 | 0.80 | RORA (0.54) | EDNRALMNAEDNRBHCRTR1RAB9A | |
| SCHEMBL22088467 | 0.80 | EDNRA (0.56) | EDNRAMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL7768609 | 0.80 | KDM4E (0.67) | EDNRAMEN1KMT2ALMNAMAPT | |
| SCHEMBL7770318 | 0.79 | TNNI3 (0.55) | EDNRAMEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682016-B1 | Pyridine derivatives | ASTRAZENECA AB (SE) | 2001-07-11 | — | — | EP | claimed |
| EP-0682016-A1 | Pyridine derivatives | ZENECA LIMITED (GB) | 1995-11-15 | — | — | EP | claimed |
| EP-0682016-B1 | Pyridine derivatives | ASTRAZENECA AB (SE) | 2001-07-11 | — | — | EP | disclosed |
| EP-0682016-A1 | Pyridine derivatives | ZENECA LIMITED (GB) | 1995-11-15 | — | — | EP | disclosed |