Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | NSD2 | O96028 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | CASP1 | P29466 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | EDNRA | P25101 | 3/20 | 0.53 |
| ▸ | EDNRB | P24530 | 2/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890499 | 0.80 | KDM4E (0.62) | KDM4ETSHRNSD2HSD17B10ALDH1A1 | |
| SCHEMBL7772536 | 0.80 | EDNRA (0.67) | KDM4ETSHRNSD2HSD17B10ALDH1A1 | |
| SCHEMBL7770323 | 0.80 | EDNRA (0.69) | KDM4ETSHRNSD2HSD17B10ALDH1A1 | |
| SCHEMBL7764513 | 0.80 | EDNRA (0.67) | KDM4EHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL7768388 | 0.80 | EDNRA (0.67) | KDM4ETSHRNSD2HSD17B10ALDH1A1 | |
| SCHEMBL6981201 | 0.78 | SLC40A1 (0.73) | MEN1KMT2ATDP1 | |
| SCHEMBL16110825 | 0.78 | ALDH1A1 (0.68) | KDM4ETSHRNSD2HSD17B10ALDH1A1 | |
| SCHEMBL2762847 | 0.78 | SMN1; SMN2 (0.62) | KDM4ETSHRNSD2HSD17B10ALDH1A1 | |
| SCHEMBL8395841 | 0.77 | EDNRA (0.55) | KDM4ETSHRNSD2HSD17B10ALDH1A1 | |
| SCHEMBL8392571 | 0.77 | EDNRA (0.67) | TSHREDNRAEDNRBHCRTR1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682016-B1 | Pyridine derivatives | ASTRAZENECA AB (SE) | 2001-07-11 | — | — | EP | disclosed |