SCHEMBL7768873

SCHEMBL7768873

Clc1ccccc1-c1nnn(Cc2ccccc2)n1

nearest known ligand 0.68

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 7/20 0.68
L3MBTL1 Q9Y468 5/20 0.68
SMN1; SMN2 Q16637 4/20 0.67
ALDH1A1 P00352 3/20 0.67
HPGD P15428 2/20 0.67
MEN1 O00255 1/20 0.67
KMT2A Q03164 1/20 0.67
ATM Q13315 1/20 0.59
ESR1 P03372 2/20 0.55
NPC1 O15118 5/20 0.55
POLB P06746 2/20 0.53
THRB P10828 1/20 0.52
TP53 P04637 1/20 0.50
MAPT P10636 1/20 0.50
HDAC6 Q9UBN7 2/20 0.49
MAPK1 P28482 1/20 0.48
TDP1 Q9NUW8 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7774794 0.84 RAB9A (0.67) RAB9AL3MBTL1SMN1; SMN2ALDH1A1HPGD
SCHEMBL15560849 0.84 SMN1; SMN2 (0.55) RAB9AL3MBTL1SMN1; SMN2ALDH1A1HPGD
SCHEMBL7768870 0.84 HPGD (0.51) RAB9AL3MBTL1SMN1; SMN2ALDH1A1HPGD
SCHEMBL4413466 0.81 RAB9A (1.00) RAB9AL3MBTL1SMN1; SMN2ALDH1A1HPGD
SCHEMBL7776374 0.79 RAB9A (0.60) RAB9AL3MBTL1SMN1; SMN2ALDH1A1HPGD
SCHEMBL15559403 0.79 RAB9A (0.56) RAB9AL3MBTL1SMN1; SMN2ALDH1A1HPGD
SCHEMBL15559580 0.79 RAB9A (0.52) RAB9AL3MBTL1SMN1; SMN2ALDH1A1HPGD
SCHEMBL1733064 0.78 RAB9A (0.59) RAB9AL3MBTL1SMN1; SMN2ALDH1A1HPGD
SCHEMBL13232422 0.78 L3MBTL1 (0.59) RAB9AL3MBTL1SMN1; SMN2ALDH1A1HPGD
SCHEMBL457699 0.77 RAB9A (0.50) RAB9AL3MBTL1SMN1; SMN2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0788487-B1 PROCESS FOR THE PREPARATION OF TETRAZOLES NOVARTIS AG (CH) 2001-07-25 EP disclosed
EP-0788487-A1 PROCESS FOR THE PREPARATION OF TETRAZOLES Novartis AG (CH) 1997-08-13 EP disclosed
WO-1996013489-A1 PROCESS FOR THE PREPARATION OF TETRAZOLES NOVARTIS AG (CH) 1996-05-09 WO disclosed