SCHEMBL7769484

SCHEMBL7769484

CCCC(=O)Nc1ccccc1Nc1ccc(C)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.62
ALDH1A1 P00352 3/20 0.60
MAPT P10636 2/20 0.60
HPGD P15428 1/20 0.60
HDAC1 Q13547 2/20 0.53
HDAC3 O15379 1/20 0.53
HDAC2 Q92769 1/20 0.53
HDAC10 Q969S8 1/20 0.53
NPC1 O15118 3/20 0.53
RAB9A P51151 3/20 0.53
HTT P42858 2/20 0.51
TP53 P04637 2/20 0.50
MTNR1B P49286 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.49
PKM P14618 1/20 0.48
POLB P06746 1/20 0.47
LMNA P02545 1/20 0.47
KMT2A Q03164 1/20 0.47
GAA P10253 1/20 0.46
TDP1 Q9NUW8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11423199 0.90 HDAC1 (0.52) MAPK1ALDH1A1MAPTHPGDHDAC1
SCHEMBL28118557 0.89 ALDH1A1 (0.71) MAPK1ALDH1A1MAPTHPGDNPC1
SCHEMBL9489551 0.83 NPC1 (0.54) ALDH1A1MAPTHPGDHDAC1HDAC3
SCHEMBL8361539 0.80 TP53 (0.75) ALDH1A1MAPTHPGDHDAC1HDAC3
SCHEMBL5613323 0.79 NPC1 (0.61) MAPK1ALDH1A1MAPTHPGDNPC1
SCHEMBL10338297 0.78 RAB9A (0.59) MAPTHPGDNPC1RAB9AHTT
SCHEMBL9491413 0.77 KMT2A (0.57) MAPK1ALDH1A1MAPTHDAC1HDAC3
SCHEMBL29315244 0.77 MAPK1 (1.00) MAPK1ALDH1A1MAPTHPGDHTT
SCHEMBL6658490 0.77 MAPK1 (0.69) MAPK1ALDH1A1MAPTHPGDHDAC1
SCHEMBL11427164 0.76 MAPT (0.53) MAPK1ALDH1A1MAPTHPGDHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1115720-A2 NOVEL N-(IMINOMETHYL)AMINE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2001-07-18 EP claimed
WO-2000017191-A2 N-(IMINOMETHYL)AMINE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2000-03-30 WO claimed