Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 6/20 | 0.39 |
| ▸ | CES1 | P23141 | 6/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.34 |
| ▸ | IAPP | P10997 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16663701 | 0.87 | MAPT (0.52) | MAPTKMT2ACES2CES1HDAC3 | |
| SCHEMBL7771051 | 0.84 | CES2 (0.43) | MAPTKMT2ACES2CES1HDAC3 | |
| SCHEMBL7769247 | 0.82 | TDP1 (0.45) | MAPTKMT2ACES2CES1FFAR3 | |
| SCHEMBL17473897 | 0.81 | CES1 (0.55) | MAPTKMT2ACES2CES1HDAC3 | |
| SCHEMBL5194043 | 0.81 | KMT2A (0.59) | MAPTKMT2ACES2CES1HDAC3 | |
| SCHEMBL23437836 | 0.79 | KMT2A (0.65) | MAPTKMT2ACES2CES1TSHR | |
| SCHEMBL18043750 | 0.79 | TDP1 (0.47) | MAPTKMT2ACES2CES1HDAC3 | |
| SCHEMBL10885739 | 0.79 | TDP1 (0.47) | MAPTKMT2ACES2CES1HDAC3 | |
| SCHEMBL109288 | 0.78 | — | — | |
| SCHEMBL20913016 | 0.78 | CES1 (0.58) | MAPTKMT2ACES2CES1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765879-B1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO CO (JP) | 2001-02-14 | — | — | EP | disclosed |
| US-5861429-A | MITICIDES AND ANTHELMINTICS | SANKYO COMPANY, LIMITED (JP) | 1999-01-19 | — | — | US | disclosed |
| EP-0765879-A1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO COMPANY LIMITED (JP) | 1997-04-02 | — | — | EP | disclosed |