SCHEMBL7770340

SCHEMBL7770340

CC(=O)c1cccc(C#N)n1

nearest known ligand 0.65

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.49
ALDH1A1 P00352 2/20 0.42
SOS2 Q07890 1/20 0.41
KDM4E B2RXH2 2/20 0.39
ALOX15 P16050 1/20 0.39
TSHR P16473 1/20 0.39
ACMSD Q8TDX5 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
TGFBR1 P36897 1/20 0.37
SRC P12931 1/20 0.36
LMNA P02545 1/20 0.36
CES1 P23141 1/20 0.36
CTSK P43235 1/20 0.36
IRAK4 Q9NWZ3 1/20 0.35
GRM5 P41594 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyridine SCHEMBL7770372 0.89 ALDH1A1 (0.42) AHRALDH1A1SOS2KDM4EALOX15
SCHEMBL1244495 0.82 KDM4E (0.61) AHRSOS2KDM4EALOX15TSHR
SCHEMBL15336497 0.81 AHR (0.42) AHRSOS2SRCCTSK
SCHEMBL2956687 0.81 AHR (0.49) AHRSOS2KDM4EALOX15TSHR
SCHEMBL5387510 0.81 AHR (0.49) AHRALDH1A1SOS2KDM4EALOX15
SCHEMBL17963045 0.81 ALDH1A1 (0.42) AHRALDH1A1KDM4EALOX15TSHR
SCHEMBL31098054 0.81 ALDH1A1 (0.42) AHRALDH1A1KDM4EALOX15TSHR
SCHEMBL9326696 0.80 AHR (0.46) AHRALDH1A1SOS2KDM4EALOX15
SCHEMBL3815890 0.80 BRD4 (0.50) AHRKDM4EGRM5
SCHEMBL9323548 0.80 AHR (0.46) AHRSOS2KDM4EALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119612485-A Nitrogen-doped asphalt-based hard carbon material and preparation method and application thereof 武汉天钠科技有限公司 2025-03-14 CN claimed
CN-117402193-A Chiral oxazoline-cobalt picolinite compound and synthetic method and application thereof 郑州大学 2024-01-16 CN claimed
CN-117402193-B Chiral oxazoline-pyridine-cobalt imine compound, and synthetic method and application thereof 郑州大学 2026-01-30 CN disclosed
CN-119612485-A Nitrogen-doped asphalt-based hard carbon material and preparation method and application thereof 武汉天钠科技有限公司 2025-03-14 CN disclosed
CN-117402193-A Chiral oxazoline-cobalt picolinite compound and synthetic method and application thereof 郑州大学 2024-01-16 CN disclosed
CN-117402193-A Chiral oxazoline-cobalt picolinite compound and synthetic method and application thereof 郑州大学 2024-01-16 CN disclosed
US-20230159510-A1 NOVEL PRMT5 INHIBITORS AMGEN INC. (US) 2023-05-25 US disclosed
US-20230159510-A1 NOVEL PRMT5 INHIBITORS AMGEN INC. (US) 2023-05-25 US disclosed
WO-2023027948-A1 JAK2 INHIBITORS AND METHODS OF USE THEREOF RELAY THERAPEUTICS, INC. (US) 2023-03-02 WO disclosed
EP-4103558-A1 NOVEL PRMT5 INHIBITORS Amgen Inc. (US) 2022-12-21 EP disclosed
CN-107849013-B Cyanopyrrolidines as DUB inhibitors for the treatment of cancer 特殊治疗有限公司 2022-03-29 CN disclosed
US-5376685-A Arylhydrazones using as SAMDC inhibitors CIBA-GEIGY CORPORATION (US) 1994-12-27 US disclosed
US-5350696-A 2-acetyl-6-cyanopyridines and their use as intermediates in the synthesis of oligo-2,6-pyridines STERLING WINTHROP, INC. (US) 1994-09-27 US disclosed
US-5350696-A 2-acetyl-6-cyanopyridines and their use as intermediates in the synthesis of oligo-2,6-pyridines STERLING WINTHROP, INC. (US) 1994-09-27 US disclosed
US-5350696-A 2-acetyl-6-cyanopyridines and their use as intermediates in the synthesis of oligo-2,6-pyridines STERLING WINTHROP, INC. (US) 1994-09-27 US disclosed
US-5238941-A S-adenosylmethionine decarboxylase inhibitors CIBA-GEIGY CORPORATION (US) 1993-08-24 US disclosed
EP-0335832-B1 ARYL HYDRAZONES CIBA-GEIGY AG (CH) 1993-02-10 EP disclosed
US-5118709-A Decarboxylase enzyme inhibitors; antitumor agents CIBA-GEIGY CORPORATION (US) 1992-06-02 US disclosed
US-4971986-A ANTITUMOR AGENTS CIBA-GEIGY CORPORATION (US) 1990-11-20 US disclosed
EP-0335832-A2 Aryl hydrazones CIBA-GEIGY AG (CH) 1989-10-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230159510-A1 NOVEL PRMT5 INHIBITORS PRMT5, PRMT1, PRMT3 AHR 4159/4885ALDH1A1 3191/4885SOS2 4125/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.