Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | KCNJ11 | Q14654 | 7/20 | 0.61 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.49 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.49 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MDM4 | O15151 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL777051 | 0.86 | NPC1 (0.54) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9400456 | 0.83 | NPC1 (0.68) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28599674 | 0.82 | NPC1 (0.66) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11116162 | 0.81 | CYP1A2 (0.46) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29124158 | 0.81 | CYP1A2 (0.59) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4642544 | 0.81 | NPC1 (1.00) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30184438 | 0.81 | NPC1 (1.00) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29512053 | 0.78 | NPC1 (0.60) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9197662 | 0.78 | CYP1A2 (0.65) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30237970 | 0.77 | MEN1 (0.60) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673998-B2 | Polymer compositions with improved cold flow | BRIDGESTONE CORPORATION (JP) | 2014-03-18 | — | — | US | disclosed |
| US-20120071583-A1 | POLYMER COMPOSITIONS WITH IMPROVED COLD FLOW | BRIDGESTONE CORPORATION (JP) | 2012-03-22 | — | — | US | disclosed |