Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | ACP3 | P15309 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28933413 | 0.85 | KIF11 (0.48) | ALDH1A1TAAR1ACP3 | |
| SCHEMBL28933407 | 0.80 | LTA4H (0.48) | TSHR | |
| SCHEMBL28774583 | 0.79 | SLC6A4 (0.41) | DPP4TSHRF2ALDH1A1ACP3 | |
| SCHEMBL7870015 | 0.79 | POLB (0.39) | DPP4TSHRF2ALDH1A1HTR2A | |
| SCHEMBL16428390 | 0.79 | PTPN1 (0.38) | DPP4TSHRF2ALDH1A1ACP3 | |
| SCHEMBL30204365 | 0.78 | ESR1 (0.39) | TSHR | |
| SCHEMBL28443758 | 0.78 | TSHR (0.46) | DPP4TSHRF2HTR2ATAAR1 | |
| SCHEMBL9778287 | 0.77 | TSHR (0.40) | DPP4TSHRF2ALDH1A1HTR2A | |
| SCHEMBL21834945 | 0.77 | TSHR (0.46) | DPP4TSHRF2ALDH1A1ACP3 | |
| SCHEMBL10213399 | 0.76 | SLC6A4 (0.42) | DPP4TSHRF2TAAR1CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112830862-B | Novel fluorine-containing flame retardant, synthetic method and application thereof in nylon 6 modification | 三明学院 | 2023-04-18 | — | — | CN | claimed |
| CN-112830862-A | Novel fluorine-containing flame retardant, synthetic method and application thereof in nylon 6 modification | 三明学院 | 2021-05-25 | — | — | CN | claimed |
| EP-2951179-B1 | SPIRO-QUINAZOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISEASES AND CONDITIONS | MERCK PATENT GMBH (DE) | 2020-03-11 | — | — | EP | claimed |
| US-9708321-B2 | Spiro-quinazolinone derivatives and their use as positive allosteric modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2017-07-18 | — | — | US | claimed |
| US-20150361079-A1 | Spiro-Quinazolinone Derivatives and their Use as Positive Allosteric Modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2015-12-17 | — | — | US | claimed |
| EP-2951179-A1 | SPIRO-QUINAZOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISEASES AND CONDITIONS | Merck Patent GmbH (DE) | 2015-12-09 | — | — | EP | claimed |
| CN-104955826-A | SPIRO-QUINAZOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISEASES AND CONDITIONS | MERCK PATENT GMBH | 2015-09-30 | — | — | CN | claimed |
| WO-2014117920-A1 | SPIRO-QUINAZOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISEASES AND CONDITIONS | MERCK PATENT GMBH (DE) | 2014-08-07 | — | — | WO | claimed |
| EP-1119536-A1 | NOVEL BROMINE-CONTAINING 1,2-BIS(PHENYL) TETRAFLUORO ETHANES AND METHOD OF IMPARTING FLAME RETARDANCY TO FLAMMABLE MATERIALS | Great Lakes Chemical Corporation (US) | 2001-08-01 | — | — | EP | claimed |
| WO-2000020363-A1 | NOVEL BROMINE-CONTAINING 1,2-BIS(PHENYL) TETRAFLUORO ETHANES AND METHOD OF IMPARTING FLAME RETARDANCY TO FLAMMABLE MATERIALS | GREAT LAKES CHEMICAL CORPORATION (US) | 2000-04-13 | — | — | WO | claimed |
| CN-112830862-B | Novel fluorine-containing flame retardant, synthetic method and application thereof in nylon 6 modification | 三明学院 | 2023-04-18 | — | — | CN | disclosed |
| CN-112830862-B | Novel fluorine-containing flame retardant, synthetic method and application thereof in nylon 6 modification | 三明学院 | 2023-04-18 | — | — | CN | disclosed |
| US-20220221619-A1 | MATERIALS FOR FORMING A NUCLEATION-INHIBITING COATING AND DEVICES INCORPORATING SAME | OTI LUMIONICS INC. (CA) | 2022-07-14 | — | — | US | disclosed |
| CN-112830862-A | Novel fluorine-containing flame retardant, synthetic method and application thereof in nylon 6 modification | 三明学院 | 2021-05-25 | — | — | CN | disclosed |
| CN-112830862-A | Novel fluorine-containing flame retardant, synthetic method and application thereof in nylon 6 modification | 三明学院 | 2021-05-25 | — | — | CN | disclosed |
| WO-2014117920-A1 | SPIRO-QUINAZOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISEASES AND CONDITIONS | MERCK PATENT GMBH (DE) | 2014-08-07 | — | — | WO | disclosed |
| EP-1119536-A1 | NOVEL BROMINE-CONTAINING 1,2-BIS(PHENYL) TETRAFLUORO ETHANES AND METHOD OF IMPARTING FLAME RETARDANCY TO FLAMMABLE MATERIALS | Great Lakes Chemical Corporation (US) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020363-A1 | NOVEL BROMINE-CONTAINING 1,2-BIS(PHENYL) TETRAFLUORO ETHANES AND METHOD OF IMPARTING FLAME RETARDANCY TO FLAMMABLE MATERIALS | GREAT LAKES CHEMICAL CORPORATION (US) | 2000-04-13 | — | — | WO | disclosed |
| EP-0822459-A1 | Electrostatic image developing toner | HODOGAYA CHEMICAL CO LTD (JP) | 1998-02-04 | — | — | EP | disclosed |
| US-5693445-A | CONSISTS OF A POLYMERIC BINDER, COLORANT AND XANTHENE-TYPE DYE AS CHARGE CONTROL AGENT | HODOGAYA CHEMICAL CO., LTD. (JP) | 1997-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150361079-A1 | Spiro-Quinazolinone Derivatives and their Use as Positive Allosteric Modulators of mGluR4 | GRM4, GRIA4, GRIK4 | DPP4 778/4885TSHR 839/4885F2 4883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.