Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8079406 | 1.00 | MEN1 (0.47) | MEN1KMT2AALDH1A1ADRB1ADRB3 | |
| SCHEMBL8477434 | 1.00 | MEN1 (0.47) | MEN1KMT2AALDH1A1ADRB1ADRB3 | |
| SCHEMBL7964059 | 0.89 | CYP3A4 (0.52) | MEN1KMT2AALDH1A1ADRB1ADRB3 | |
| SCHEMBL7963443 | 0.89 | CYP3A4 (0.52) | MEN1KMT2AALDH1A1ADRB1ADRB3 | |
| SCHEMBL8479423 | 0.88 | ADRB3 (0.53) | MEN1KMT2AALDH1A1ADRB1ADRB3 | |
| SCHEMBL6949036 | 0.88 | MEN1 (0.53) | MEN1KMT2AALDH1A1ADRB1ADRB3 | |
| SCHEMBL8477891 | 0.87 | MEN1 (0.55) | MEN1KMT2AALDH1A1ADRB1ADRB3 | |
| SCHEMBL7822048 | 0.86 | MEN1 (0.45) | MEN1KMT2AALDH1A1ADRB1ADRB3 | |
| SCHEMBL8482072 | 0.86 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1ADRB1ADRB3 | |
| SCHEMBL8479493 | 0.86 | MAPK1 (0.54) | MEN1KMT2AALDH1A1ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265409-B1 | ANTIINFLAMMATORY AGENTS | ASTRAZENECA AB (SE) | 2001-07-24 | — | — | US | disclosed |
| EP-1115706-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| EP-1115401-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| EP-0984961-B1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| US-6143751-A | Pyridine derivatives and pharmaceutical compositions containing them | ASTRAZENECA UK LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |
| EP-1037889-A1 | NOVEL COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-09-27 | — | — | EP | disclosed |
| EP-1019375-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-07-19 | — | — | EP | disclosed |
| WO-2000018730-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |
| WO-2000018731-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |
| EP-0984961-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-03-15 | — | — | EP | disclosed |
| US-5977105-A | Compounds | ASTRA PHARMAEUTICALS LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| WO-1999029686-A1 | NOVEL COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |
| WO-1998043971-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-08 | — | — | WO | disclosed |
| WO-1998042669-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | disclosed |
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |