Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP12 | P39900 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6508653 | 0.87 | TSHR (0.67) | TSHRALDH1A1SMN1; SMN2LMNAMMP2 | |
| SCHEMBL7429874 | 0.82 | TSHR (0.43) | TSHRALDH1A1SMN1; SMN2LMNAMMP2 | |
| SCHEMBL30274357 | 0.80 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL15527823 | 0.79 | KMT2A (0.43) | TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL13259140 | 0.79 | TSHR (0.56) | TSHRALDH1A1SMN1; SMN2LMNAMMP2 | |
| SCHEMBL3682764 | 0.79 | TSHR (0.56) | TSHRALDH1A1SMN1; SMN2LMNAMMP2 | |
| SCHEMBL20213990 | 0.79 | IDO1 (0.50) | IDO1TDP1L3MBTL1AGXTHTT | |
| SCHEMBL8396350 | 0.79 | ALDH1A1 (0.54) | TSHRALDH1A1SMN1; SMN2LMNAMMP2 | |
| SCHEMBL15000482 | 0.79 | TSHR (0.50) | TSHRALDH1A1SMN1; SMN2LMNAMMP2 | |
| SCHEMBL22766620 | 0.78 | TSHR (0.54) | TSHRALDH1A1SMN1; SMN2LMNAMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10369140-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180133198-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-17 | — | — | US | disclosed |
| US-9901572-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |
| US-20170216263-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-08-03 | — | — | US | disclosed |
| US-9663466-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |
| US-20160031816-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-02-04 | — | — | US | disclosed |
| US-9187424-B1 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150315144-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-11-05 | — | — | US | disclosed |
| US-8791091-B2 | Aryl dihydropyridinone and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-07-29 | — | — | US | disclosed |
| US-20130143843-A1 | ARYL DIHYDROPYRIDINONE AND PIPERIDINONE MGAT2 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2013-06-06 | — | — | US | disclosed |
| US-6320085-B1 | REACTING BENZYL ALCOHOL DERIVATIVE WITH 1 TO 3 MOLAR EQUIVALENTS OF SPECIFIED ALCOHOL IN PRESENCE OF ACID, LEWIS ACID, METAL OXIDE OR METAL CARBONATE, ISOLATING RESULTING ETHER, STABILIZING BY ADDITION OF BASE AND/OR ANTIOXIDANT | AGRO-CHEMIE NOVENYVEDOSZER GYARTO ERTEKESITO EST FORGALMAZO KFT. (HU) | 2001-11-20 | — | — | US | disclosed |
| EP-0939749-B1 | PROCESS FOR THE PREPARATION OF BENZYL-ETHERS | AGRO CHEMIE NOEVENYVEDOESZER G (HU) | 2001-07-18 | — | — | EP | disclosed |
| EP-0939749-A1 | PROCESS FOR THE PREPARATION OF BENZYL-ETHERS | Agro-Chemie Növenyvedöszer Gyárto Ertékesito Es Forgalmazo KFT. (HU) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998022416-A1 | PROCESS FOR THE PREPARATION OF BENZYL-ETHERS | AGRO-CHEMIE NÖVÉNYVÉDÖSZER GYÁRTÓ ÉRTÉKESITÓ ÉS FORGALMAZÓ KFT. (HU) | 1998-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133198-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | DGAT2, MGAT2, MGAT1 | TSHR 2899/4885ALDH1A1 284/4885SMN1; SMN2 4109/4885 |
| US-20130143843-A1 | ARYL DIHYDROPYRIDINONE AND PIPERIDINONE MGAT2 INHIBITORS | DGAT2, MGAT2, MGAT1 | TSHR 2913/4885ALDH1A1 288/4885SMN1; SMN2 4064/4885 |
| US-20170216263-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | DGAT2, MGAT2, MGAT1 | TSHR 2899/4885ALDH1A1 284/4885SMN1; SMN2 4109/4885 |
| US-20160031816-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | DGAT2, MGAT2, MGAT1 | TSHR 2899/4885ALDH1A1 284/4885SMN1; SMN2 4109/4885 |
| US-10369140-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | DGAT2, MGAT2, MGAT1 | TSHR 2899/4885ALDH1A1 284/4885SMN1; SMN2 4109/4885 |
| US-20150315144-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | DGAT2, MGAT2, MGAT1 | TSHR 2899/4885ALDH1A1 284/4885SMN1; SMN2 4109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.