Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7519236 | 0.84 | DRD2 (0.65) | HTR1ADRD2ADRA1AHTR7DRD4 | |
| Bromide SCHEMBL7773481 | 0.83 | TSHR (0.48) | HTR1ADRD2HTR7DRD4HTR6 | |
| Bromide SCHEMBL7528934 | 0.83 | DRD2 (0.64) | HTR1ADRD2ADRA1AHTR7DRD4 | |
| SCHEMBL7524765 | 0.81 | DRD4 (0.48) | HTR1ADRD2DRD4HTR2A | |
| SCHEMBL7776870 | 0.77 | DRD2 (0.48) | HTR1AADRA1BDRD2ADRA1AADRA1D | |
| Bromide SCHEMBL7775429 | 0.77 | DRD2 (0.48) | HTR1AADRA1BDRD2ADRA1AADRA1D | |
| SCHEMBL6930794 | 0.72 | DRD2 (0.66) | HTR1AADRA1BDRD2ADRA1AADRA1D | |
| SCHEMBL6934502 | 0.72 | DRD2 (0.66) | HTR1AADRA1BDRD2ADRA1AADRA1D | |
| SCHEMBL9760272 | 0.72 | DRD2 (0.67) | HTR1AADRA1BDRD2ADRA1AADRA1D | |
| SCHEMBL7528032 | 0.71 | HTR1A (0.58) | HTR1AADRA1BDRD2ADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117663-A2 | 2-PIPERAZINO ALKYLAMINO BENZOAZOLE DERIVATIVES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 2001-07-25 | — | — | EP | claimed |
| WO-2000018767-A2 | 2-PIPERAZINO ALKYLAMINO BENZOAZOLE DERIVATIVES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 2000-04-06 | — | — | WO | claimed |