Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | GBA1 | P04062 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27979632 | 0.82 | ALDH1A1 (0.82) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL7769746 | 0.82 | KDM4E (0.69) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL7776116 | 0.81 | NPC1 (0.70) | KDM4EALDH1A1MAPTHSD17B10LMNA | |
| SCHEMBL4379063 | 0.78 | KDM4E (0.82) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL8906560 | 0.78 | GBA1 (0.65) | ALDH1A1LMNAGBA1 | |
| SCHEMBL14218031 | 0.75 | ALDH1A1 (0.70) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL17940608 | 0.75 | ALDH1A1 (0.73) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL1374171 | 0.74 | ALDH1A1 (0.69) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL4378942 | 0.74 | KDM4E (0.65) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL2829296 | 0.74 | KDM4E (0.62) | KDM4EALDH1A1MAPTHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574906-B1 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO (JP) | 2001-08-22 | — | — | EP | disclosed |
| US-5380724-A | Inhibitors of lipid peroxidation | GYOGYSZERKUTATO INTEZET KFT (HU) | 1995-01-10 | — | — | US | disclosed |