Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | HTT | P42858 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | MITF | O75030 | 2/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | RNF4 | P78317 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | CASP2 | P42575 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18952169 | 0.83 | KMT2A (0.59) | KMT2ANPC1HTTLMNAMAPT | |
| SCHEMBL8688649 | 0.83 | KMT2A (0.59) | KMT2ANPC1HTTLMNAMAPT | |
| SCHEMBL23054838 | 0.81 | KMT2A (0.58) | KMT2ANPC1HTTLMNAMAPT | |
| SCHEMBL9081388 | 0.81 | NPC1 (0.76) | KMT2ANPC1HTTLMNAMAPT | |
| SCHEMBL11640329 | 0.80 | KMT2A (0.65) | KMT2ANPC1HTTLMNAMAPT | |
| SCHEMBL11128513 | 0.80 | NPC1 (0.63) | KMT2ANPC1HTTLMNAMAPT | |
| SCHEMBL549173 | 0.79 | KMT2A (0.63) | KMT2ANPC1HTTLMNAMAPT | |
| SCHEMBL5492921 | 0.79 | KMT2A (0.63) | KMT2ANPC1HTTLMNAMAPT | |
| SCHEMBL1720835 | 0.79 | MAPT (0.59) | KMT2ANPC1HTTLMNAMAPT | |
| SCHEMBL2636162 | 0.78 | NPC1 (0.61) | KMT2ANPC1HTTLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574906-B1 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO (JP) | 2001-08-22 | — | — | EP | disclosed |
| US-5380724-A | Inhibitors of lipid peroxidation | GYOGYSZERKUTATO INTEZET KFT (HU) | 1995-01-10 | — | — | US | disclosed |
| EP-0574906-A2 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-12-22 | — | — | EP | disclosed |