SCHEMBL7775428

SCHEMBL7775428

Cc1ccc(OP(=O)(O)C#N)c([N+](=O)[O-])c1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.46
CYP3A4 P08684 1/20 0.46
ALDH1A1 P00352 10/20 0.44
MAPT P10636 5/20 0.44
KDM4E B2RXH2 3/20 0.44
GAA P10253 1/20 0.44
LMNA P02545 2/20 0.43
S1PR4 O95977 1/20 0.43
MAPK1 P28482 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.42
HTT P42858 1/20 0.42
NPC1 O15118 3/20 0.42
RAB9A P51151 3/20 0.42
HPGD P15428 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7775199 0.89 TSHR (0.46) TSHRCYP3A4ALDH1A1MAPTKDM4E
SCHEMBL8456531 0.80 ALDH1A1 (0.49) ALDH1A1MAPTKDM4EMAPK1SMN1; SMN2
SCHEMBL8456524 0.80 ALDH1A1 (0.49) ALDH1A1MAPTKDM4EMAPK1SMN1; SMN2
SCHEMBL3737965 0.78 TSHR (0.50) TSHRCYP3A4ALDH1A1MAPTKDM4E
SCHEMBL7775426 0.75 TSHR (0.50) TSHRCYP3A4ALDH1A1MAPTGAA
SCHEMBL9687621 0.73 TSHR (0.64) TSHRCYP3A4ALDH1A1MAPTKDM4E
SCHEMBL22579601 0.72 ALDH1A1 (0.56) TSHRCYP3A4ALDH1A1MAPTKDM4E
SCHEMBL7775198 0.72 TSHR (0.50) TSHRCYP3A4ALDH1A1MAPTKDM4E
Lithium Ion SCHEMBL8329179 0.72 TSHR (0.46) TSHRCYP3A4ALDH1A1MAPTKDM4E
SCHEMBL7169934 0.72 ALDH1A1 (0.45) TSHRCYP3A4ALDH1A1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2001507707-A 2001-06-12 JP claimed
EP-0948503-A1 PREPARATION OF CYANOPHOSPHONATES FROM PHOSPHATES AND CYANIDE MONSANTO COMPANY (US) 1999-10-13 EP claimed
US-5861525-A Method for preparing cyanophosphonate derivatives from phosphate esters and cyanide MONSANTO COMPANY (US) 1999-01-19 US claimed
WO-1998029424-A1 PREPARATION OF CYANOPHOSPHONATES FROM PHOSPHATES AND CYANIDE MONSANTO COMPANY (US) 1998-07-09 WO claimed
US-5861525-A Method for preparing cyanophosphonate derivatives from phosphate esters and cyanide MONSANTO COMPANY (US) 1999-01-19 US disclosed