Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.62 |
| ▸ | DRD2 | P14416 | 4/20 | 0.61 |
| ▸ | DRD4 | P21917 | 2/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7775598 | 1.00 | HTR1A (0.62) | HTR1ADRD2DRD4DRD3KDM4E | |
| Hydrochloric Acid SCHEMBL7776010 | 0.99 | HTR1A (0.61) | HTR1ADRD2DRD4DRD3KDM4E | |
| Hydrochloric Acid SCHEMBL7776012 | 0.99 | HTR1A (0.61) | HTR1ADRD2DRD4DRD3KDM4E | |
| SCHEMBL9334170 | 0.87 | KDM4E (0.65) | HTR1ADRD2DRD4DRD3KDM4E | |
| SCHEMBL7776025 | 0.87 | KDM4E (0.65) | HTR1ADRD2DRD4DRD3KDM4E | |
| SCHEMBL7775626 | 0.84 | HTR1A (0.77) | HTR1ADRD2DRD4DRD3KDM4E | |
| SCHEMBL5796448 | 0.82 | KDM4E (0.70) | HTR1ADRD2DRD4DRD3KDM4E | |
| Hydrochloric Acid SCHEMBL1375643 | 0.81 | ALDH1A1 (0.69) | HTR1ADRD2DRD4DRD3KDM4E | |
| SCHEMBL4171472 | 0.78 | KDM4E (0.65) | HTR1ADRD2DRD4DRD3KDM4E | |
| SCHEMBL4171468 | 0.78 | ALDH1A1 (0.65) | HTR1ADRD2DRD4DRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123926-A1 | Piperazine derivatives for treatment of CNS disorders | JOHN WYETH & BROTHER LIMITED (GB) | 2001-08-16 | — | — | EP | disclosed |
| US-5369103-A | Anxiolytic agents, cental nervous system disorders | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-11-29 | — | — | US | disclosed |
| EP-0506905-A1 | PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1992-10-07 | — | — | EP | disclosed |
| WO-1992006960-A1 | PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1992-04-30 | — | — | WO | disclosed |