Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 8/20 | 0.77 |
| ▸ | OPRD1 known ✓ | P41143 | 8/20 | 0.77 |
| ▸ | OPRK1 known ✓ | P41145 | 6/20 | 0.77 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.77 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.77 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.77 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL7770906 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3477475 | 1.00 | OPRM1 (0.77) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3477724 | 0.97 | OPRM1 (0.79) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Morphine SCHEMBL22234325 | 0.90 | OPRD1 (0.75) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL3476234 | 0.90 | OPRD1 (0.75) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| Codeine SCHEMBL2322854 | 0.89 | OPRM1 (0.86) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL3476236 | 0.89 | OPRD1 (0.68) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3476555 | 0.89 | OPRD1 (0.91) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL13998952 | 0.88 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL14192921 | 0.88 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255502-B1 | DRUG DELIVERY THROUGH SKIN, INTESTINAL, ORAL, NASAL, AND RECTAL MUCOSA ENHANCED BY FORMING INCLUSION COMPLEXES WITH CYCLODEXTRINS (SOLUBILIZERS/STABILIZERS) AND ACID-ADDITION SALTS OF DRUGS (CODEINE) AND A FATTY/BILE ACID | FARMARC NEDERLAND B.V. (NL) | 2001-07-03 | — | — | US | claimed |
| JP-2001508027-A | — | — | 2001-06-19 | — | — | JP | claimed |
| EP-1024833-A1 | Pharmaceutical composition containing acid addition salt of basic drug | FARMARC NEDERLAND B.V. (NL) | 2000-08-09 | — | — | EP | claimed |
| WO-1998002187-A1 | PHARMACEUTICAL COMPOSITION CONTAINING ACID ADDITION SALT OF BASIC DRUG | FARMARC NEDERLAND B.V. (NL) | 1998-01-22 | — | — | WO | claimed |
| US-6255502-B1 | DRUG DELIVERY THROUGH SKIN, INTESTINAL, ORAL, NASAL, AND RECTAL MUCOSA ENHANCED BY FORMING INCLUSION COMPLEXES WITH CYCLODEXTRINS (SOLUBILIZERS/STABILIZERS) AND ACID-ADDITION SALTS OF DRUGS (CODEINE) AND A FATTY/BILE ACID | FARMARC NEDERLAND B.V. (NL) | 2001-07-03 | — | — | US | disclosed |
| EP-1024833-A1 | Pharmaceutical composition containing acid addition salt of basic drug | FARMARC NEDERLAND B.V. (NL) | 2000-08-09 | — | — | EP | disclosed |
| WO-1998002187-A1 | PHARMACEUTICAL COMPOSITION CONTAINING ACID ADDITION SALT OF BASIC DRUG | FARMARC NEDERLAND B.V. (NL) | 1998-01-22 | — | — | WO | disclosed |