Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444865 | 0.92 | ABCB1 (0.43) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL7780747 | 0.92 | HDAC8 (0.52) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL7775508 | 0.92 | HDAC8 (0.52) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL7775518 | 0.92 | HDAC8 (0.62) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL30039059 | 0.92 | HDAC8 (0.62) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL7776748 | 0.92 | HDAC8 (0.62) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL8444852 | 0.90 | HDAC8 (0.46) | HDAC8HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL7775563 | 0.90 | HDAC8 (0.52) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL7775479 | 0.90 | HDAC8 (0.52) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL8444331 | 0.89 | HDAC8 (0.53) | HDAC8ABCB1HDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318801-B2 | Cinnamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2012-11-27 | — | — | US | disclosed |
| US-20110224294-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-09-15 | — | — | US | disclosed |
| US-7994357-B2 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-08-09 | — | — | US | disclosed |
| US-7994357-B2 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-08-09 | — | — | US | disclosed |
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2010-10-07 | — | — | US | disclosed |
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2010-10-07 | — | — | US | disclosed |
| EP-2236503-A1 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NatureWise Biotech & Medicals Corporation (TW) | 2010-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | SMN1; SMN2, HDAC1, HDAC5 | HDAC8 14/4885ABCB1 2280/4885HDAC1 2/4885 |
| US-20110224294-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | SMN1; SMN2, HDAC1, HDAC5 | HDAC8 14/4885ABCB1 2280/4885HDAC1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.