Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.45 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30039059 | 1.00 | HDAC8 (0.62) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL7776748 | 1.00 | HDAC8 (0.62) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL8444331 | 0.93 | HDAC8 (0.53) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL20029756 | 0.92 | HDAC8 (0.52) | HDAC8ABCB1TNFRSF1APTPN1MEN1 | |
| SCHEMBL7775563 | 0.92 | HDAC8 (0.52) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL7775479 | 0.92 | HDAC8 (0.52) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL7776314 | 0.92 | HDAC8 (0.52) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL8440487 | 0.91 | HDAC8 (0.51) | HDAC8ABCB1TNFRSF1APTPN1MEN1 | |
| SCHEMBL7775463 | 0.91 | HDAC8 (0.51) | HDAC8ABCB1HDAC1HDAC3HDAC2 | |
| SCHEMBL12299976 | 0.91 | HDAC8 (0.59) | HDAC8ABCB1HDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230038230-A1 | COMPOSITION AND METHOD FOR TREATING A DRUG-RESISTANT CANCER | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2023-02-09 | — | — | US | disclosed |
| US-11045435-B2 | Methods for treating ocular diseases | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2021-06-29 | — | — | US | disclosed |
| US-20180085329-A1 | METHODS FOR TREATING OCULAR DISEASES | SPRINGSKY BIOMED COMPANY LIMITED (TW) | 2018-03-29 | — | — | US | disclosed |
| EP-2277387-B1 | NEW USE OF HISTONE DEACETYLASE INHIBITORS IN CHANGING MRJP3 PROTEIN IN ROYAL JELLY | NATUREWISE BIOTECH & MEDICALS CORP (TW) | 2016-10-19 | — | — | EP | disclosed |
| US-9427424-B2 | Use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2016-08-30 | — | — | US | disclosed |
| US-20140288166-A1 | USE OF HISTONE DEACETYLASE INHIBITORS IN CHANGING MRJP3 PROTEIN IN ROYAL JELLY | NATUREWISE BIOTECH & MEDICALS CORP (TW) | 2014-09-25 | — | — | US | disclosed |
| US-8784873-B2 | Use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2014-07-22 | — | — | US | disclosed |
| EP-2236503-B1 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORP (TW) | 2014-02-26 | — | — | EP | disclosed |
| US-8318801-B2 | Cinnamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2012-11-27 | — | — | US | disclosed |
| US-20110224294-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-09-15 | — | — | US | disclosed |
| US-7994357-B2 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-08-09 | — | — | US | disclosed |
| US-7994357-B2 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-08-09 | — | — | US | disclosed |
| US-20110020462-A1 | NEW USE OF HISTONE DEACETYLASE INHIBITORS IN CHANGING MRJP3 PROTEIN IN ROYAL JELLY | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-01-27 | — | — | US | disclosed |
| EP-2277387-A1 | New use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly | NatureWise Biotech & Medicals Corporation (TW) | 2011-01-26 | — | — | EP | disclosed |
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2010-10-07 | — | — | US | disclosed |
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2010-10-07 | — | — | US | disclosed |
| EP-2236503-A1 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NatureWise Biotech & Medicals Corporation (TW) | 2010-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11045435-B2 | Methods for treating ocular diseases | ALDH1A2, AQP1, AQP3 | HDAC8 1027/4885ABCB1 2777/4885HDAC1 506/4885 |
| US-20110020462-A1 | NEW USE OF HISTONE DEACETYLASE INHIBITORS IN CHANGING MRJP3 PROTEIN IN ROYAL JELLY | BRPF3, BRD3, BRDT | HDAC8 16/4885ABCB1 4577/4885HDAC1 5/4885 |
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | SMN1; SMN2, HDAC1, HDAC5 | HDAC8 14/4885ABCB1 2280/4885HDAC1 2/4885 |
| US-20180085329-A1 | METHODS FOR TREATING OCULAR DISEASES | ALDH1A2, AQP1, AQP3 | HDAC8 1027/4885ABCB1 2777/4885HDAC1 506/4885 |
| US-20110224294-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | SMN1; SMN2, HDAC1, HDAC5 | HDAC8 14/4885ABCB1 2280/4885HDAC1 2/4885 |
| US-20140288166-A1 | USE OF HISTONE DEACETYLASE INHIBITORS IN CHANGING MRJP3 PROTEIN IN ROYAL JELLY | BRPF3, BRD3, BRDT | HDAC8 16/4885ABCB1 4474/4885HDAC1 5/4885 |
| US-20230038230-A1 | COMPOSITION AND METHOD FOR TREATING A DRUG-RESISTANT CANCER | MYC, MYCBP, HDAC8 | HDAC8 3/4885ABCB1 405/4885HDAC1 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.