Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.55 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.55 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.55 |
| ▸ | TNKS2 | Q9H2K2 | 9/20 | 0.43 |
| ▸ | TNKS | O95271 | 7/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.43 |
| ▸ | AXIN2 | Q9Y2T1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7783545 | 0.84 | PARP1 (0.56) | PARP1PARP3PARP15TNKS2TNKS | |
| SCHEMBL7783296 | 0.80 | PARP1 (0.65) | PARP1PARP3PARP15TNKS2TNKS | |
| SCHEMBL7781343 | 0.80 | PARP1 (0.60) | PARP1PARP3PARP15TNKS2TNKS | |
| SCHEMBL7776883 | 0.80 | PARP1 (0.60) | PARP1PARP3PARP15TNKS2TNKS | |
| SCHEMBL7776848 | 0.78 | PARP1 (0.52) | PARP1PARP3PARP15TNKS2TNKS | |
| SCHEMBL7782149 | 0.77 | PARP1 (0.51) | PARP1PARP3PARP15TNKS2TNKS | |
| SCHEMBL7781362 | 0.73 | HTR2C (0.64) | PARP1PARP3PARP15TNKS2TNKS | |
| SCHEMBL421328 | 0.71 | PARP1 (1.00) | PARP1PARP3PARP15TNKS2TNKS | |
| SCHEMBL7776836 | 0.71 | PARP1 (0.53) | PARP1PARP3PARP15TNKS2TNKS | |
| SCHEMBL6368624 | 0.71 | PARP1 (0.76) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142881-A1 | POLY(ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES | MEIJI SEIKA KAISHA LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |