Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.56 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.56 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.56 |
| ▸ | TNKS | O95271 | 5/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.42 |
| ▸ | AXIN2 | Q9Y2T1 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7776752 | 0.84 | PARP1 (0.55) | PARP1PARP3PARP15TNKSTNKS2 | |
| SCHEMBL7783296 | 0.83 | PARP1 (0.65) | PARP1PARP3PARP15TNKSTNKS2 | |
| SCHEMBL1082422 | 0.79 | HPGD (0.55) | PARP1ALDH1A1HIF1AGPR84HPGD | |
| SCHEMBL7776848 | 0.79 | PARP1 (0.52) | PARP1PARP3PARP15TNKSTNKS2 | |
| SCHEMBL7781343 | 0.77 | PARP1 (0.60) | PARP1PARP3PARP15TNKSTNKS2 | |
| SCHEMBL7782149 | 0.75 | PARP1 (0.51) | PARP1PARP3PARP15TNKSTNKS2 | |
| SCHEMBL9844062 | 0.75 | HPGD (0.56) | PARP1ALDH1A1HIF1AHPGDMEN1 | |
| SCHEMBL9843755 | 0.75 | HPGD (0.59) | PARP1ALDH1A1HIF1AHPGDMEN1 | |
| SCHEMBL421328 | 0.72 | PARP1 (1.00) | PARP1PARP3PARP15TNKSTNKS2 | |
| SCHEMBL7781362 | 0.71 | HTR2C (0.64) | PARP1PARP3PARP15TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142881-A1 | POLY(ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES | MEIJI SEIKA KAISHA LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |