Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 4/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5667730 | 0.85 | KDM4E (0.51) | KDM4EL3MBTL1TSHRPTGDR2CNR1 | |
| SCHEMBL5667733 | 0.85 | KDM4E (0.51) | KDM4EL3MBTL1TSHRPTGDR2CNR1 | |
| SCHEMBL5667861 | 0.85 | KDM4E (0.42) | KDM4EL3MBTL1TSHRPTGDR2CNR1 | |
| SCHEMBL5667855 | 0.83 | CASP3 (0.45) | KDM4EL3MBTL1TSHRCASP1 | |
| SCHEMBL28750003 | 0.83 | CASP3 (0.45) | KDM4EL3MBTL1TSHRCASP1 | |
| SCHEMBL5667865 | 0.83 | L3MBTL1 (0.42) | KDM4EL3MBTL1TSHRPTGDR2CNR1 | |
| SCHEMBL27583491 | 0.83 | L3MBTL1 (0.42) | KDM4EL3MBTL1TSHRPTGDR2CNR1 | |
| SCHEMBL7390761 | 0.83 | KDM4E (0.42) | KDM4EL3MBTL1TSHRPTGDR2CNR1 | |
| SCHEMBL5667043 | 0.80 | KDM4E (0.45) | KDM4EL3MBTL1TSHRPTGDR2CNR1 | |
| SCHEMBL27517492 | 0.80 | KDM4E (0.45) | KDM4EL3MBTL1TSHRPTGDR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184244-B1 | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases | IDUN PHARMACEUTICALS, INC. | 2001-02-06 | — | — | US | disclosed |