Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | MIF | P14174 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771075 | 0.89 | ESR2 (0.57) | ESR2BACE1NPC1RAB9ATP53 | |
| SCHEMBL7777278 | 0.85 | HSP90AA1 (0.50) | ESR2BACE1NPC1RAB9ATP53 | |
| SCHEMBL7778555 | 0.82 | HSD17B10 (0.54) | ESR2ABL1ABCB1BCRHSD17B10 | |
| SCHEMBL29817108 | 0.82 | ABL1 (0.44) | ESR2BACE1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL11078733 | 0.81 | ESR2 (0.61) | ESR2BACE1NPC1RAB9ATP53 | |
| SCHEMBL29473775 | 0.81 | CA1 (0.51) | RAB9AMEN1KMT2AABL1ABCB1 | |
| Methane SCHEMBL28995945 | 0.81 | MEN1 (0.43) | ESR2BACE1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL7775876 | 0.80 | ESR2 (0.59) | ESR2BACE1NPC1RAB9ATP53 | |
| SCHEMBL1847771 | 0.79 | GAA (0.65) | ESR2BACE1NPC1RAB9ATP53 | |
| SCHEMBL7777345 | 0.79 | ESR2 (0.57) | ESR2BACE1NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121125-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2001-08-08 | — | — | EP | claimed |
| WO-2000021535-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2000-04-20 | — | — | WO | claimed |
| EP-1121125-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000021535-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2000-04-20 | — | — | WO | disclosed |