Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.43 |
| ▸ | GYS1 | P13807 | 6/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7778156 | 0.89 | PTGS2 (0.48) | LRRK2PTGS2PTGS1GYS1 | |
| SCHEMBL7777620 | 0.86 | LRRK2 (0.60) | LRRK2PTGS2PTGS1MAP2K7MAP2K4 | |
| SCHEMBL7773326 | 0.85 | LRRK2 (0.68) | LRRK2PTGS2PTGS1MAP2K7MAP2K4 | |
| SCHEMBL7773014 | 0.85 | LRRK2 (0.61) | LRRK2PTGS2PTGS1MAP2K7MAP2K4 | |
| SCHEMBL7773215 | 0.84 | LRRK2 (0.77) | LRRK2PTGS2MAP2K7MAP2K4GYS1 | |
| SCHEMBL7779654 | 0.84 | LRRK2 (0.60) | LRRK2PTGS2PTGS1MAP2K7MAP2K4 | |
| SCHEMBL7779954 | 0.84 | LRRK2 (0.60) | LRRK2PTGS2PTGS1MAP2K7MAP2K4 | |
| SCHEMBL7778058 | 0.83 | MAPT (0.58) | LRRK2PTGS2PTGS1MAPTCNR1 | |
| SCHEMBL7780859 | 0.82 | PTGS2 (0.54) | LRRK2PTGS2PTGS1MAP2K7MAP2K4 | |
| SCHEMBL7777792 | 0.82 | GYS1 (0.54) | LRRK2PTGS2PTGS1GYS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772597-B1 | 3,4-SUBSTITUTED PYRAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-1127878-A1 | 3,4 - substituted pyrazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-29 | — | — | EP | disclosed |
| US-6028072-A | 3,4-substituted pyrazoles for the treatment of inflammation | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | disclosed |
| EP-0772597-A1 | 3,4-SUBSTITUTED PYRAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| US-5580985-A | ANTIARTHRITIC AGENT; SIDE EFFECT REDUCTION | G. D. SEARLE & CO. (US) | 1996-12-03 | — | — | US | disclosed |
| WO-1996003385-A1 | 3,4-SUBSTITUTED PYRAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |
| US-5486534-A | 3,4-substituted pyrazoles for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-01-23 | — | — | US | disclosed |