Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30899523 | 0.96 | TDP1 (0.41) | TDP1CA1CA2CA9CA12 | |
| Hydrochloric Acid SCHEMBL30626113 | 0.93 | TDP1 (0.39) | TDP1CA1CA2CA9CA12 | |
| Hydrochloric Acid SCHEMBL29009368 | 0.93 | TDP1 (0.39) | TDP1CA1CA2CA9CA12 | |
| Hydrochloric Acid SCHEMBL28072575 | 0.93 | TDP1 (0.39) | TDP1CA1CA2CA9CA12 | |
| Hydrochloric Acid SCHEMBL719621 | 0.93 | TDP1 (0.39) | TDP1CA1CA2CA9CA12 | |
| Hydrochloric Acid SCHEMBL31456068 | 0.93 | TDP1 (0.39) | TDP1CA1CA2CA9CA12 | |
| Hydrochloric Acid SCHEMBL3190347 | 0.93 | TDP1 (0.39) | TDP1CA1CA2CA9CA12 | |
| Hydrochloric Acid SCHEMBL8118405 | 0.93 | TDP1 (0.39) | TDP1CA1CA2CA9CA12 | |
| Hydrochloric Acid SCHEMBL8007753 | 0.93 | TDP1 (0.39) | TDP1CA1CA2CA9CA12 | |
| Benzene SCHEMBL4445625 | 0.93 | TDP1 (0.44) | TDP1CA1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140756-A2 | SYNTHESIS OF DIHYDROHONOKIOL COMPOSITIONS | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040532-A2 | SYNTHESIS OF DIHYDROHONOKIOL COMPOSITIONS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-07-13 | — | — | WO | disclosed |
| EP-0212708-B1 | PROCESS FOR THE HYDROBORATION OF ALKENES AND ALKYNES | METALLGESELLSCHAFT AG (DE) | 1990-03-14 | — | — | EP | disclosed |
| US-4731463-A | Process of hydroboronizing alkenes and alkynes | METALLGESELLSCHAFT AKTIENGESELLSCHAFT (DE) | 1988-03-15 | — | — | US | disclosed |
| EP-0212708-A2 | Process for the hydroboration of alkenes and alkynes | METALLGESELLSCHAFT AG (DE) | 1987-03-04 | — | — | EP | disclosed |