SCHEMBL7777412

SCHEMBL7777412

CCOC(=O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2

nearest known ligand 0.81

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 20/20 0.81
PTGDR Q13258 11/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7777416 1.00 PTGIR (0.81) PTGIRPTGDR
SCHEMBL7776672 0.90 PTGIR (1.00) PTGIRPTGDR
SCHEMBL7776667 0.90 PTGIR (1.00) PTGIRPTGDR
SCHEMBL7772454 0.85 PTGIR (0.78) PTGIRPTGDR
SCHEMBL7772453 0.85 PTGIR (0.78) PTGIRPTGDR
SCHEMBL9017258 0.82 PTGIR (0.85) PTGIRPTGDR
SCHEMBL7772428 0.81 PTGIR (0.54) PTGIRPTGDR
SCHEMBL7772431 0.81 PTGIR (0.73) PTGIRPTGDR
SCHEMBL7777367 0.81 PTGIR (0.73) PTGIRPTGDR
SCHEMBL7779785 0.78 PTGIR (0.56) PTGIRPTGDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0749424-B1 NAPHTHALENE DERIVATIVES AS PROSTAGLANDIN I2 AGONISTS FUJISAWA PHARMACEUTICAL CO (JP) 2001-09-12 EP disclosed
US-5863918-A HYPOTENSIVE AGENTS, ANTICOAGULANTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-01-26 US disclosed
US-5763489-A ANTICOAGULANTS AND HYPOTENSIVE AGENTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-06-09 US disclosed
WO-1995024393-A1 NAPHTHALENE DERIVATIVES AS PROSTAGLANDIN I2 AGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-09-14 WO disclosed