Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 9/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7776640 | 0.90 | PTGIR (0.68) | PTGIRPTGDR2TBXAS1PTGDR | |
| SCHEMBL7772438 | 0.85 | PTGIR (0.51) | PTGIRSIGMAR1HTR1AADRA1A | |
| SCHEMBL8583025 | 0.83 | PTGIR (0.47) | PTGIRPTGDR2 | |
| SCHEMBL7777390 | 0.81 | PTGIR (0.47) | PTGIRPTGDR2PTGDRSIGMAR1 | |
| SCHEMBL7777416 | 0.78 | PTGIR (0.81) | PTGIRPTGDR | |
| SCHEMBL7777412 | 0.78 | PTGIR (0.81) | PTGIRPTGDR | |
| SCHEMBL9005581 | 0.78 | PTGIR (0.70) | PTGIRTBXAS1SIGMAR1HTR1AADRA1A | |
| SCHEMBL9005657 | 0.77 | PTGIR (0.53) | PTGIRTBXAS1 | |
| SCHEMBL7772457 | 0.77 | PTGIR (0.53) | PTGIRPTGDR2PTGDR | |
| SCHEMBL7772428 | 0.75 | PTGIR (0.54) | PTGIRPTGDR2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749424-B1 | NAPHTHALENE DERIVATIVES AS PROSTAGLANDIN I2 AGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-09-12 | — | — | EP | disclosed |
| US-5863918-A | HYPOTENSIVE AGENTS, ANTICOAGULANTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-01-26 | — | — | US | disclosed |
| US-5763489-A | ANTICOAGULANTS AND HYPOTENSIVE AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0749424-A1 | NAPHTHALENE DERIVATIVES AS PROSTAGLANDIN I2 AGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-12-27 | — | — | EP | disclosed |
| WO-1995024393-A1 | NAPHTHALENE DERIVATIVES AS PROSTAGLANDIN I2 AGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-09-14 | — | — | WO | disclosed |