Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 17/20 | 0.72 |
| ▸ | PTGDR | Q13258 | 9/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713218 | 0.93 | PTGIR (0.63) | PTGIRPTGDRPTGER4PTGER3PTGER2 | |
| SCHEMBL7720294 | 0.85 | PTGIR (0.54) | PTGIRPTGDRPTGER4PTGER3PTGER2 | |
| SCHEMBL7779671 | 0.85 | PTGIR (0.77) | PTGIRPTGDRCYP19A1CA1CA2 | |
| SCHEMBL7772466 | 0.84 | PTGIR (1.00) | PTGIRPTGDRPTGER3PTGER1 | |
| SCHEMBL7776687 | 0.80 | PTGIR (0.82) | PTGIRPTGDRPTGER3PTGER1 | |
| SCHEMBL7778633 | 0.80 | PTGIR (0.80) | PTGIRPTGDRPTGER3PTGER1 | |
| SCHEMBL7776652 | 0.78 | PTGIR (0.66) | PTGIRPTGDRPTGER4PTGER3PTGER2 | |
| SCHEMBL7713222 | 0.78 | PTGIR (0.89) | PTGIRPTGDRPTGER4PTGER3PTGER2 | |
| SCHEMBL7716647 | 0.75 | PTGIR (0.50) | PTGIRPTGDRPTGER4PTGER3PTGER2 | |
| SCHEMBL8413532 | 0.74 | CYP19A1 (0.57) | PTGIRCYP19A1CA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749424-B1 | NAPHTHALENE DERIVATIVES AS PROSTAGLANDIN I2 AGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-09-12 | — | — | EP | disclosed |
| US-5863918-A | HYPOTENSIVE AGENTS, ANTICOAGULANTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-01-26 | — | — | US | disclosed |
| US-5763489-A | ANTICOAGULANTS AND HYPOTENSIVE AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0749424-A1 | NAPHTHALENE DERIVATIVES AS PROSTAGLANDIN I2 AGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-12-27 | — | — | EP | disclosed |
| WO-1995024393-A1 | NAPHTHALENE DERIVATIVES AS PROSTAGLANDIN I2 AGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-09-14 | — | — | WO | disclosed |