Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.78 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP4 | P49662 | 1/20 | 0.56 |
| ▸ | CASP5 | P51878 | 1/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655533 | 0.93 | HRH4 (0.77) | HRH4HRH3CASP1CASP4CASP5 | |
| SCHEMBL30296862 | 0.84 | HRH4 (0.70) | HRH4HRH3CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL10678810 | 0.84 | HRH4 (0.70) | HRH4HRH3CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL2797830 | 0.83 | HRH4 (0.68) | HRH4HRH3CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL10674357 | 0.83 | HRH4 (0.68) | HRH4HRH3CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL31503138 | 0.83 | HRH4 (0.68) | HRH4HRH3CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL606966 | 0.80 | HRH4 (0.92) | HRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL7774442 | 0.80 | HRH4 (0.57) | HRH4HRH3CASP1CASP4CASP5 | |
| SCHEMBL8900887 | 0.79 | CASP1 (0.78) | HRH4HRH3CASP1CASP4CASP5 | |
| SCHEMBL8891695 | 0.79 | CASP1 (0.78) | HRH4HRH3CASP1CASP4CASP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574906-B1 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO (JP) | 2001-08-22 | — | — | EP | disclosed |
| US-5380724-A | Inhibitors of lipid peroxidation | GYOGYSZERKUTATO INTEZET KFT (HU) | 1995-01-10 | — | — | US | disclosed |
| EP-0574906-A2 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-12-22 | — | — | EP | disclosed |